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The melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides consisting of α-melanocyte-stimulating hormone (α-MSH), β-melanocyte-stimulating hormone (β-MSH), and γ-melanocyte-stimulating hormone (γ-MSH) that are produced by cells in the pars intermedia of the anterior lobe of the pituitary ...
α-Melanocyte-stimulating hormone (α-MSH) is an endogenous peptide hormone and neuropeptide of the melanocortin family, with a tridecapeptide structure and the amino acid sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH 2.
The incidence of melasma also increases in patients with thyroid disease. [7] It is thought that the overproduction of melanocyte-stimulating hormone brought on by stress can cause outbreaks of this condition. Other rare causes of melasma include allergic reaction to medications and cosmetics.
Illustration of a melanocyte Micrograph of melanocytes in the epidermis. Through a process called melanogenesis, melanocytes produce melanin, which is a pigment found in the skin, eyes, hair, nasal cavity, and inner ear. This melanogenesis leads to a long-lasting pigmentation, which is in contrast to the pigmentation that originates from ...
The pars intermedia is responsible for secreting α-melanocyte-stimulating hormone, and corticotropin-like intermediate peptide. [5] It is prominent only during the fetal stage and is otherwise negligible. The characteristic pattern of skin hyperpigmentation seen during pregnancy may be a result of increased circulating maternal a-MSH (which ...
Melanocortins were originally named so because their earliest known function was in melanogenesis. It is now known that the melanocortin system regulates diverse functions throughout the body, including inflammatory response, fibrosis, melanogenesis, steroidogenesis, energy homeostasis, sexual function, and exocrine gland function. [3] [4] [1]
Melasma is a common skin condition that’s likely to occur in women during their reproductive years. ... which function like mortar between skin cells to strengthen the skin barrier. This formula ...
For pregnant women, the emergence of linea nigra is attributed to an increased production of melanocyte-stimulating hormone by the placenta. [3] This physiological phenomenon is concomitant with the occurrence of melasma and darkened nipples.