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Emergency 130 milligrams potassium iodide doses provide 100 mg iodide (the other 30 mg is the potassium in the compound), [17] which is roughly 700 times larger than the normal nutritional need (see recommended dietary allowance) for iodine, which is 150 micrograms (0.15 mg) of iodine (as iodide) per day for an adult.
Potassium iodide (KI) and potassium iodate ... If a person consumes a dose of one of these chemical compounds, his or her thyroid may saturate with stable iodine, ...
Ingestion of this large dose of non-radioactive iodine minimises the uptake of radioactive iodine by the thyroid gland. [19] Before the advent of organic chelating agents, salts of iodide were given orally in the treatment of lead or mercury poisoning, such as heavily popularized by Louis Melsens and many nineteenth and early twentieth century ...
Other sources state that pure potassium iodide solution in water was eventually used for most of the thyroid protection after this accident. [26] There is "strong scientific evidence" for potassium iodide thyroid protection to help prevent thyroid cancer. Potassium iodide does not provide immediate protection but can be a component of a general ...
Four inorganic compounds are used as iodide sources, depending on the producer: potassium iodate, potassium iodide, sodium iodate, and sodium iodide. Any of these compounds supplies the body with the iodine required for the biosynthesis of thyroxine (T 4 ) and triiodothyronine (T 3 ) hormones by the thyroid gland.
[14] [15] Potassium iodide (KI) is typically used for this purpose. [16] However, unjustified self-medicated preventive administration of stable KI is not recommended in order to avoid disturbing the normal thyroid function. Such a treatment must be carefully dosed and requires an appropriate KI amount prescribed by a specialised physician.
The Wolff–Chaikoff effect is an effective means of rejecting a large quantity of imbibed iodide, and therefore preventing the thyroid from synthesizing large quantities of thyroid hormone. [7] Excess iodide transiently inhibits thyroid iodide organification. In individuals with a normal thyroid, the gland eventually escapes from this ...
Iodide transport is a key step in the biosynthesis of the thyroid hormones T4 and T3. [5] [6] For example, potassium perchlorate competitively inhibits the active iodide transport mechanism in the thyroid gland, which has the capacity to selectively concentrate iodide against a large concentration gradient. [5] [6]
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