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The post-splenectomy platelet count may rise to abnormally high levels (thrombocytosis), leading to an increased risk of potentially fatal clot formation. Mild thrombocytosis may be observed after a splenectomy due to the lack of sequestering and destruction of platelets that would normally be carried out by the spleen.
Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that results in blood clots forming in small blood vessels throughout the body. [2] This results in a low platelet count, low red blood cells due to their breakdown, and often kidney, heart, and brain dysfunction. [1]
An overwhelming post-splenectomy infection (OPSI) is a rare but rapidly fatal infection occurring in individuals following removal (or permanent dysfunction) of the spleen. The infections are typically characterized by either meningitis or sepsis , and are caused by encapsulated organisms including Streptococcus pneumoniae . [ 3 ]
Other causes of reactive thrombocythemia include: post surgery, iron deficiency, drugs, and rebound effect after bone marrow suppression. [8] Research suggests that thrombocytosis can also occur after physical exercise, and is triggered by hemoconcentration and the release of platelets from the liver, lungs and spleen. [3] [9]
Splenic infarct seen on CT Healed splenic infarct. Several factors may increase the tendency for clot formation, such as specific infections (such as infectious mononucleosis, [9] [dubious – discuss] [better source needed] cytomegalovirus infection, [10] malaria, [11] or babesiosis [12]), inherited clotting disorders (thrombophilia, such as Factor V Leiden, antiphospholipid syndrome ...
Ricky Pearsall shooting timeline Aug. 31, 2024 : Pearsall is shot in the chest in an attempted robbery while walking in the Union Square area of San Francisco on his way to an autograph signing event.
The original procedure also consisted of an esophageal transection, splenectomy, vagotomy, and pyloroplasty. [ citation needed ] The Sugiura procedure was originally associated with significant morbidity and mortality ; in recent years, though, this procedure and its modifications have been performed in many hepatobiliary and pancreatic ...
Even though there is a consensus regarding the short-term efficacy of splenectomy, findings on its long-term efficacy and side-effects are controversial. [37] [39] After splenectomy, 11.6–75 percent of ITP cases relapsed, and 8.7–40 percent of ITP cases had no response to splenectomy.