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Watson and Crick's calculations from Gosling and Franklin's photography gave crucial parameters for the size and structure of the helix. [ 16 ] Photo 51 became a crucial data source [ 17 ] that led to the development of the DNA model and confirmed the prior postulated double helical structure of DNA, which were presented in the series of three ...
The double-helix model of DNA structure was first published in the journal Nature by James Watson and Francis Crick in 1953, [6] (X,Y,Z coordinates in 1954 [7]) based on the work of Rosalind Franklin and her student Raymond Gosling, who took the crucial X-ray diffraction image of DNA labeled as "Photo 51", [8] [9] and Maurice Wilkins, Alexander Stokes, and Herbert Wilson, [10] and base-pairing ...
The DNA model shown (far right) is a space-filling, or CPK, model of the DNA double helix. Animated molecular models, such as the wire, or skeletal, type shown at the top of this article, allow one to visually explore the three-dimensional (3D) structure of DNA. Another type of DNA model is the space-filling, or CPK, model.
Watson and Crick completed their model, which is now accepted as the first correct model of the double helix of DNA. On 28 February 1953 Crick interrupted patrons' lunchtime at The Eagle pub in Cambridge, England to announce that he and Watson had "discovered the secret of life". [209] Pencil sketch of the DNA double helix by Francis Crick in 1953
The tertiary arrangement of DNA's double helix in space includes B-DNA, A-DNA, and Z-DNA. Triple-stranded DNA structures have been demonstrated in repetitive polypurine:polypyrimidine Microsatellite sequences and Satellite DNA. B-DNA is the most common form of DNA in vivo and is a more narrow, elongated helix than A-DNA. Its wide major groove ...
The Path to The Double Helix: Discovery of DNA. MacMillan. ISBN 978-0-486-68117-7. (with foreword by Francis Crick; revised in 1994, with a 9-page postscript.) Watson, James D. (1980). The Double Helix: A Personal Account of the Discovery of the Structure of DNA. Atheneum. ISBN 978-0-689-70602-8. (first published in 1968) Wilkins, Maurice (2003).
Original - The molecular structure of the DNA double helix. The path of the DNA backbone is shown in orange. The path of the DNA backbone is shown in orange. Detail of the two canonical base pairs, thymine - adenosine (linked by two hydrogen bonds ) and cytosine - guanine (three hydrogen bonds), is shown on the right.
The initial double helix model discovered, now termed B-form DNA is by far the most common conformation in cells. [12] Two additional rarer helical conformations that also naturally occur were identified in the 1970s: A-form DNA , and Z-form DNA .