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Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
SIRT1 protein promotes homologous recombination in human cells and is involved in recombinational repair of DNA breaks. [ 29 ] SIRT6 is a chromatin -associated protein and in mammalian cells is required for base excision repair of DNA damage . [ 30 ]
SRT-1720 is an experimental drug that was studied by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. The compound has been studied in animals, but safety and efficacy in humans have not been established.
International law enforcement agencies have arrested several members of an online community that groomed and abused children, officials said Thursday. U.S. Homeland Security, Europol and the ...
Hubbard, a big man with intense blue eyes and a five-o'clock shadow, greets me gruffly. "You don't look like Business Insider," he says. "You look like Rising S."
PHOENIX — At least one person is dead and multiple people are injured Monday after private jets collided at an Arizona airport, authorities said, the latest incident at a time of heightened ...
UniProt Archive (UniParc) is a comprehensive and non-redundant database, which contains all the protein sequences from the main, publicly available protein sequence databases. [17] Proteins may exist in several different source databases, and in multiple copies in the same database.
SRT-1460 is a drug in development by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1.It has similar activity in animal studies to the known SIRT1 activator resveratrol, but is closer in potency to SRT-1720.