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With SSRIs, duration of treatment does not appear associated with the severity of withdrawal symptoms. [24] One hypothesis is that after the antidepressant is discontinued, there is a temporary (but in some cases long-lasting) deficiency in the brain of one or more essential neurotransmitters that regulate mood, such as serotonin, dopamine ...
The major limitation of SSRIs concerns their delay of action. It appears that the clinical efficacy of SSRIs becomes evident only after a few weeks. [217] SSRIs can be combined with a host of other drugs including bupropion, α 2 adrenergic antagonists (e.g., yohimbine) as well as some of the atypical antipsychotics. The augmentation agents are ...
Post-SSRI sexual dysfunction (PSSD) [63] [64] refers to a set of symptoms reported by some people who have taken SSRIs or other serotonin reuptake-inhibiting (SRI) drugs, in which sexual dysfunction symptoms persist for at least three months [65] [66] [67] after ceasing to take the drug. The status of PSSD as a legitimate and distinct pathology ...
Online, people claim they get brain zaps after stopping use of drugs like Lexapro (escitalopram), Cymbalta (duloxetine), and Paxil (paroxetine), but they can happen when you stop taking any type ...
One of the safer techniques simply reduces your current dosage to a complete stop, then waits for it to clear your body before starting the new antidepressant. You may need to use this technique ...
Generally, tapering is done is to avoid or minimize withdrawal symptoms that arise from neurobiological adaptation to the drug. [1] [2] Prescribed psychotropic drugs that may require tapering due to this physical dependence include opioids, [3] [4] [5] selective serotonin reuptake inhibitors, [6] antipsychotics, [7] anticonvulsants, [8] and ...
One theory to explain antidepressant-related weight gain is that psychotropic medications such as antidepressants can affect neurotransmitters involved in eating behavior, causing an increase in ...
If this is not sufficient, a serotonin antagonist such as cyproheptadine may be used. [1] In those with a high body temperature, active cooling measures may be needed. [1] The number of cases of SS that occur each year is unclear. [3] With appropriate medical intervention the risk of death is low, likely less than 1%. [7]