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Heck-type cross coupling of phenylboronic acid and alkenes and alkynes has been demonstrated. [9] Aryl azides and nitroaromatics can also be generated from phenylboronic acid. [4] Phenylboronic acid can also be regioselectively halodeboronated using aqueous bromine, chlorine, or iodine: [10] PhB(OH) 2 + Br 2 + H 2 O → PhBr + B(OH) 3 + HBr
4-Formylphenyl boronic acid crystallizes in colorless needles [2] or is obtained as an odorless, whitish powder, which dissolves little in cold but better in hot water. The compound is quite stable [4] and readily forms dimers and cyclic trimeric anhydrides, which complicate purification and tend to protodeboronize, a secondary reaction that occurs frequently in the Suzuki coupling, with ...
Aminomethylbenzoic acid (more precisely, 4-aminomethylbenzoic acid or p-aminomethylbenzoic acid, PAMBA) is an antifibrinolytic. [1] See also. 4-Aminobenzoic acid;
The general structure of a boronic acid, where R is a substituent. A boronic acid is an organic compound related to boric acid (B(OH) 3) in which one of the three hydroxyl groups (−OH) is replaced by an alkyl or aryl group (represented by R in the general formula R−B(OH) 2). [1]
4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC 50 of 9.1nM, and 870x selectivity for FAAH over the related enzyme MAGL, which it inhibits with an IC 50 of 7900nM. [1]
Phenoxyacetic acid is a white or clear crystalline compound at room temperature. [2] When impure, it can appear to be a light tan to brown. The compound has a solubility in water of 12 g/L and is highly soluble in organic solvents including ethanol, diethyl ether and benzene. Phenoxyacetic acid is a weak acid and weak base with a pKa of 3.7. [1 ...
4-Methylphenethylamine (4MPEA), also known as para-methylphenethylamine, is an organic compound with the chemical formula of C 9 H 13 N.4MPEA is a human trace amine associated receptor 1 (TAAR1) agonist, [2] a property which it shares with its monomethylated phenethylamine isomers, such as amphetamine (α-methylphenethylamine), β-methylphenethylamine, and N-methylphenethylamine (a trace amine).
1-Boc-4-AP (tert-butyl 4-(phenylamino)piperidine-1-carboxylate) is a compound used as an intermediate in the manufacture of fentanyl, as well as various related derivatives such as butyrylfentanyl, furanylfentanyl, benzylfentanyl and homofentanyl, among others.