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Its anxiolytic and hepatotoxicity activities have been investigated. [7] [8] [9]The major kavalactones (except for desmethoxyyangonin) potentiate GABA A receptors, which may underlie the anxiolytic and sedative properties of kava.
Yangonin is one of the six major kavalactones found in the kava plant. [1] It has been shown to possess binding affinity for the cannabinoid receptor CB 1 (K i = 0.72 μM), and selectivity vs. the CB 2 receptor (K i >10 μM) where it behaves as an agonist.
Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na + and Ca 2+ channels. [1] How this effect is mediated, and to what extent this mechanism is involved in the anxiolytic and analgesic effects of kavalactones on the central nervous system, is unknown.
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Meal replacements can be used to treat diabetes by maintaining weight loss. According to the American Diabetes Association (ADA), meal replacement products can be used once or twice a day, in lieu of regular meals, to maintain weight loss for individuals with diabetes. However, that weight loss can only be maintained as long as the individual ...
Adults with mild type 2 diabetes might improve their insulin sensitivity by following a low-carb diet, thus potentially eliminating the need for medication, a new study suggests.
According to Dr. George F. Koob, the director of the National Institute on Alcohol Abuse and Alcoholism, participating in Dry January can be a great way to learn more about your drinking habits ...
Type 3 diabetes is a proposed pathological linkage between Alzheimer's disease and certain features of type 1 and type 2 diabetes. [1] Specifically, the term refers to a set of common biochemical and metabolic features seen in the brain in Alzheimer's disease, and in other tissues in diabetes; [1] [2] it may thus be considered a "brain-specific type of diabetes."
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