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In the US, infections causing gastroenteritis are the second most common infection (after the common cold), and they result in between 200 and 375 million cases of acute diarrhea [17] [18] and approximately ten thousand deaths annually, [17] with 150 to 300 of these deaths in children less than five years of age. [1]
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Peptic ulcers are most commonly caused by a bacterial Helicobacter pylori infection. [5] Epstein–Barr virus infection is another factor to induce gastric cancer. [6] [7] As well as peptic ulcers, vomiting blood may result from abnormal arteries or veins that have ruptured, including Dieulafoy's lesion and Gastric antral vascular ectasia.
[92] [65] Ammonia reduces stomach acidity, allowing the bacteria to become locally established. Arginase promotes the persistence of infection by consuming arginine; arginine is used by macrophages to produce nitric oxide, which has a strong antimicrobial effect. [91] [93] The ammonia produced to regulate pH is toxic to epithelial cells. [94]
Human infectious diseases may be characterized by their case fatality rate (CFR), the proportion of people diagnosed with a disease who die from it (cf. mortality rate).It should not be confused with the infection fatality rate (IFR), the estimated proportion of people infected by a disease-causing agent, including asymptomatic and undiagnosed infections, who die from the disease.
Peptic ulcer disease is a break in the inner lining of the stomach, the first part of the small intestine, or sometimes the lower esophagus. [1] [7] An ulcer in the stomach is called a gastric ulcer, while one in the first part of the intestines is a duodenal ulcer. [1]
About half of cases are due to peptic ulcer disease (gastric or duodenal ulcers). [3] Esophageal inflammation and erosive disease are the next most common causes. [3] In those with liver cirrhosis, 50–60% of bleeding is due to esophageal varices. [3] Approximately half of those with peptic ulcers have an H. pylori infection. [3]
Side effects include injection-site reactions, a higher risk of infection, a slight increase in melanoma risk, and rare cases of cytopenias and liver toxicity. [ 29 ] Vedolizumab is the first treatment designed specifically for the gut in moderate to severe Crohn's disease.