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The non-pathogenic and gram-negative bacteria, Pseudomonas fluorescens, is used for high level production of recombinant proteins; commonly for the development bio-therapeutics and vaccines. P. fluorescens is a metabolically versatile organism, allowing for high throughput screening and rapid development of complex proteins.
Proteins that can result from the expression of recombinant DNA within living cells are termed recombinant proteins. When recombinant DNA encoding a protein is introduced into a host organism, the recombinant protein is not necessarily produced. [1]
The following is a list of notable proteins that are produced from recombinant DNA, using biomolecular engineering. [1] In many cases, recombinant human proteins have replaced the original animal-derived version used in medicine. The prefix "rh" for "recombinant human" appears less and less in the literature.
The RAD51 protein is required for mitotic and meiotic recombination, ... Two types of recombinant product are produced. Indicated on the right side is a "crossover ...
Recombinant proteins are most commonly produced using bacteria or yeast in a bioreactor, but pharming offers the advantage to the producer that it does not require expensive infrastructure, and production capacity can be quickly scaled to meet demand, at greatly reduced cost.
The first human recombinant protein used for disease management, insulin, was introduced in 1982. [43] Biotechnology allows these peptide and protein pharmaceuticals, some of which were previously rare or difficult to obtain, to be produced in large quantity. It also reduces the risks of contaminants such as host viruses, toxins and prions.
These include--(1) medically useful proteins whose administration can correct a defective or poorly expressed gene (e.g. recombinant factor VIII, a blood-clotting factor deficient in some forms of hemophilia, [18] and recombinant insulin, used to treat some forms of diabetes [19]), (2) proteins that can be administered to assist in a life ...
Recombinant may refer to: Recombinant organism – an organism that contains a different combination of alleles from either of its parents. Recombinant DNA – a form of artificial DNA sequence; Recombinant protein - artificially produced (and often purified) protein; Recombinant virus – a virus formed by recombining genetic material
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