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Lysine acetylsalicylate, also known as aspirin DL-lysine or lysine aspirin, is a more soluble form of acetylsalicylic acid (aspirin). As with aspirin itself, it is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antithrombotic and antipyretic properties. [ 1 ]
Use at low dose: 75–100 mg orally once a day; An image of low-dose aspirin tablets (Gericare) Caution. History of gastrointestinal bleeding; Contraindications. Allergy to NSAID/aspirin; Patients with triad of asthma, rhinitis and nasal polyps; P2Y12 Inhibitors: Clopidogrel; Prasugrel; Ticagrelor
However, more recent trials were not able to replicate similar outcomes using low dose aspirin in low body weight (<70 kg) in specific subset of population studied i.e. elderly and diabetic population, and more evidence is required to study the effect of high dose aspirin in high body weight (≥70 kg). [108] [109] [110]
For years, doctors recommended that older adults at a higher risk for heart attack or stroke take a low-dose aspirin once a day to lower their risk.
Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears , nausea , abdominal pain , and a fast breathing rate . [ 1 ]
Low-dose, long-term aspirin use irreversibly blocks the formation of thromboxane A 2 in platelets, producing an inhibitory effect on platelet aggregation. [13] This effect is mediated by the irreversible blockage of COX-1 in platelets, since mature platelets don't express COX-2.
Congestive heart failure (excluding low-dose aspirin) [36] In third trimester of pregnancy [18] Persons who have undergone gastric bypass surgery [37] [38] Persons who have a history of allergic or allergic-like NSAID hypersensitivity reactions, e.g. aspirin-exacerbated respiratory disease [39]
As of 2018, the best available evidence favors low-dose thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. [5] Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of ...