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Virtual screening (VS) is a computational technique used in drug discovery to search libraries of small molecules in order to identify those structures which are most likely to bind to a drug target, typically a protein receptor or enzyme. [2] [3] Virtual screening has been defined as "automatically evaluating very large libraries of compounds ...
High-throughput screening (HTS) is a method for scientific discovery especially used in drug discovery and relevant to the fields of biology, materials science [1] and chemistry. [ 2 ] [ 3 ] Using robotics , data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to ...
This would send the simulated virtual person with diabetes ('Joy Wilson' [pseudonym]) markedly hyperglycemic in the afternoon (with a predicted blood glucose level of 18.8 mmol/L [338 mg/dL] at 2:30pm) — and leave her at significant risk of developing diabetic ketoacidosis. The simulated blood glucose profile is shown in the upper graph, and ...
Classical High throughput screening robotics are now being tied closer to cell biology, principally using technologies such as High-content screening.High throughput cell biology dictates methods that can take routine cell biology from low scale research to the speed and scale necessary to investigate complex systems, achieve high sample size, or efficiently screen through a collection.
The tandem affinity purification (TAP) method allows the high-throughput identification of proteins interactions. In contrast with the Y2H approach, the accuracy of the method can be compared to those of small-scale experiments (Collins et al., 2007) and the interactions are detected within the correct cellular environment as by co-immunoprecipitation.
Such a molecule might be extracted from a natural product or even be a drug on the market which could be improved upon (so-called "me too" drugs). Other methods, such as virtual high throughput screening, [28] where screening is done using computer-generated models and attempting to "dock" virtual libraries to a target, are also often used. [21]
HIVE Logo. The High-performance Integrated Virtual Environment (HIVE) is a distributed computing environment used for healthcare-IT and biological research, including analysis of Next Generation Sequencing (NGS) data, preclinical, clinical and post market data, adverse events, metagenomic data, etc. [1] Currently it is supported and continuously developed by US Food and Drug Administration ...
Blood glucose monitoring is the use of a glucose meter for testing the concentration of glucose in the blood ().Particularly important in diabetes management, a blood glucose test is typically performed by piercing the skin (typically, via fingerstick) to draw blood, then applying the blood to a chemically active disposable 'test-strip'.