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They occur in the parotoid glands, skin, and poison of many toads (Bufonidae family) and other amphibians, and in some plants and mushrooms. [ 1 ] [ 2 ] [ 3 ] The exact composition varies greatly with the specific source of the toxin.
The parotoid gland (alternatively, paratoid gland) is an external skin gland on the back, neck, and shoulder of some frogs (especially toads), and salamanders. It can secrete a number of milky alkaloid substances (depending on the species) known collectively as bufotoxins , which act as neurotoxins to deter predation .
The toad's primary defense system is glands that produce a poison that may be potent enough to kill a grown dog. [12] These parotoid glands also produce 5-methoxy-dimethyltryptamine (5-MeO-DMT) [13] and bufotenin (which is named after the Bufo genus of toads); both of these chemicals belong to the family of hallucinogenic tryptamines. Bufotenin ...
Ingestion of Bufo toad poison and eggs by humans has resulted in several reported cases of poisoning, [23] [24] [25] some of which resulted in death. A court case in Spain, involving a physician who dosed people with smoked Mexican Toad poison, one of his customers died after inhaling three doses, instead of the usual of only one, had images of ...
[5] [1] [4] [2] It is found in a wide variety of plant species, and is also secreted by the glands of at least one toad species, the Colorado River toad. [5] It may occur naturally in humans as well. [5] Like its close relatives dimethyltryptamine (DMT) and bufotenin (5-HO-DMT), it has been used as an entheogen in South America. [5] [6] Slang ...
Bufagin is a toxic steroid C 24 H 34 O 5 [3] obtained from toad's milk, the poisonous secretion of a skin gland on the back of the neck of a large toad (Rhinella marina, synonym Bufo marinus, the cane toad). The toad produces this secretion when it is injured, scared or provoked.
The toad venom was found to have grade 1 and 2 toxicity levels in majority of the injected areas. [3] No toxicity greater than grade 2 was observed and the effects subsided within a month. [ 3 ] These side effects included thrombocytopenia , diarrhea, mouth ulcers , and myalgia .
A variety of medical treatments are derived from the active ingredients found in the Houston Toad's toxins. The Houston toad secretes serotonin and alkaloids, some of which humans use in order to treat certain neurological and heart diseases. The toad also has alkaloids which have the ability to relieve pain and may even be stronger than ...