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The 5-HT 2A receptor is a subtype of the 5-HT 2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). [4] The 5-HT 2A receptor is a cell surface receptor, [5] but has several intracellular locations. [6] Like all 5-HT 2 receptors, the 5-HT 2A receptor is G q /G 11-protein coupled.
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [ 1 ] [ 2 ] [ 3 ] They mediate both excitatory and inhibitory neurotransmission .
The 5-HT 2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). [1] The 5-HT 2 subfamily consists of three G protein-coupled receptors (GPCRs) which are coupled to G q /G 11 and mediate excitatory neurotransmission , [ 2 ] including 5-HT 2A , 5-HT 2B , and 5-HT 2C .
Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.
Brain at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (view tree for regions of the brain) BrainMaps.org; BrainInfo (University of Washington) "Brain Anatomy and How the Brain Works". Johns Hopkins Medicine. 14 July 2021. "Brain Map". Queensland Health. 12 July 2022.
The VTA contains 5-HT 1A receptors that exert a biphasic effects on firing, with low doses of 5-HT 1A receptor agonists eliciting an increase in firing rate, and higher doses suppressing activity. The 5-HT 2A receptors expressed on dopaminergic neurons increase activity, while 5-HT 2C receptors elicit a decrease in activity. [ 39 ]
Receptors are located throughout the body including the skin, epithelia, internal organs, skeletal muscles, bones, and joints. The cutaneous receptors of the skin project in an orderly fashion to the spinal cord , and from there, via different afferent pathways ( dorsal column-medial lemniscus tract and spinothalamic tract ), to the ventral ...
This is a list of miscellaneous agonists of the serotonin receptor subtype 5-HT 2A (and other 5-HT 2 subtypes to a varying extent) ...