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“Like vitamin C, B-complex vitamins are water-soluble. As a result, they cannot be stored for later use. The body will use what it needs, and the rest is excreted as waste in the urine.”
Dietary supplements containing all eight are referred to as a vitamin B complex. Individual B vitamins are referred to by B-number or by chemical name, such as B 1 for thiamine , B 2 for riboflavin , and B 3 for niacin , [ 1 ] [ 2 ] while some are more commonly recognized by name than by number, such as pantothenic acid (B 5 ), biotin (B 7 ...
Vitamin B 3, colloquially referred to as niacin, is a vitamin family that includes three forms, or vitamers: nicotinic acid (niacin), nicotinamide (niacinamide), and nicotinamide riboside. [ 1 ] [ 2 ] All three forms of vitamin B 3 are converted within the body to nicotinamide adenine dinucleotide (NAD).
Vitamin B 12 cannot be produced by the human body, and must be obtained from the diet. [2] The body normally gets enough vitamin B 12 from the consumption of foods from animal sources. [2] Inadequate dietary intake of animal products such as eggs, meat, milk, fish, fowl (and some types of edible algae) can result in a deficiency state. [135]
The same cells in the stomach that produce gastric hydrochloric acid, the parietal cells, also produce a molecule called the intrinsic factor (IF), which binds the B 12 after its release from haptocorrin by digestion, and without which only 1% of vitamin B 12 is absorbed. Intrinsic factor (IF) is a glycoprotein, with a molecular weight of 45 kDa.
The structure of vitamin B 12 was the first low-molecular weight natural product determined by x-ray analysis rather than by chemical degradation. Thus, while the structure of this novel type of complex biomolecule was established, its chemistry remained essentially unknown; exploration of this chemistry became one of the tasks of the vitamin's chemical synthesis.
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