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A dendritic spine (or spine) is a small membrane protrusion from a neuron's dendrite that typically receives input from a single axon at the synapse.Dendritic spines serve as a storage site for synaptic strength and help transmit electrical signals to the neuron's cell body.
There are many recognized spinal diseases, some more common than others. Spinal disease also includes cervical spine diseases, which are diseases in the vertebrae of the neck. A lot of flexibility exists within the cervical spine and because of that, it is common for an individual to damage that area, especially over a long period of time.
Wallerian degeneration is an active process of degeneration that results when a nerve fiber is cut or crushed and the part of the axon distal to the injury (which in most cases is farther from the neuron's cell body) degenerates. [1]
In the spine, there is bone formation along the anterior longitudinal ligament and sometimes the posterior longitudinal ligament, which may lead to partial or complete fusion of adjacent vertebrae. The facet and sacroiliac joints tend to be uninvolved. The thoracic spine is the most common level involved. [2]
[4] [5] Intentional denervation is a valuable surgical technique for managing some medical conditions, such as renal denervation in the setting of uncontrolled hypertension. [6] Pathological denervation, by contrast, is associated with serious health sequelae , including increased infection susceptibility and tissue dysfunction.
The disease spectrum results from clonal accumulation and proliferation of cells resembling the epidermal dendritic cells called Langerhans cells, sometimes called dendritic cell histiocytosis. These cells in combination with lymphocytes , eosinophils , and normal histiocytes form typical LCH lesions that can be found in almost any organ . [ 5 ]
However, dendritic filopodia can take on spine-like morphologies even without post-synaptic density proteins, pointing to actin remodeling as the primary process responsible for the development of spines from filopodia. Cytoskeletal analyses of spines versus filopodia have found that a spine-like morphology is associated with higher numbers of ...
An apical dendrite is a dendrite that emerges from the apex of a pyramidal cell. [1] Apical dendrites are one of two primary categories of dendrites, and they distinguish the pyramidal cells from spiny stellate cells in the cortices.