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PK/PD relationships can be described by simple equations such as linear model, Emax model or sigmoid Emax model. [5] However, if a delay is observed between the drug administration and the drug effect, a temporal dissociation needs to be taken into account and more complex models exist: [6] [7] Direct vs Indirect link PK/PD models
Direct reciprocity was proposed by Robert Trivers as a mechanism for the evolution of cooperation. [1] If there are repeated encounters between the same two players in an evolutionary game in which each of them can choose either to "cooperate" or "defect", then a strategy of mutual cooperation may be favoured even if it pays each player, in the short term, to defect when the other cooperates.
Indirect effect in a simple mediation model: The indirect effect constitutes the extent to which the X variable influences the Y variable through the mediator. In linear systems, the total effect is equal to the sum of the direct and indirect (C' + AB in the model above). In nonlinear models, the total effect is not generally equal to the sum ...
Direct realism, also known as naïve realism, argues we perceive the world directly. In the philosophy of perception and philosophy of mind, direct or naïve realism, as opposed to indirect or representational realism, are differing models that describe the nature of conscious experiences; [1] [2] out of the metaphysical question of whether the world we see around us is the real world itself ...
Indirect method of difference [ edit ] If two or more instances in which the phenomenon occurs have only one circumstance in common, while two or more instances in which it does not occur have nothing in common save the absence of that circumstance; the circumstance in which alone the two sets of instances differ, is the effect, or cause, or a ...
In the direct pathway, the motor cortices send activating signals to the caudate and putamen (which together form the dorsal striatum). The cells of the direct pathway in the caudate and putamen that receive these signals are inhibitory and, once they become activated, send inhibitory signals to the GPi and SNpr and stop activity there.
In an "indirect" gap, a photon cannot be emitted because the electron must pass through an intermediate state and transfer momentum to the crystal lattice. Examples of direct bandgap materials include hydrogenated amorphous silicon and some III–V materials such as InAs and GaAs. Indirect bandgap materials include crystalline silicon and Ge.
[3] However, some researchers, such as ecology professor Tim Clutton-Brock, assert that cooperation is a more complex process. They state that helpers may receive more direct, and less indirect, gains from assisting others than is commonly reported. These gains include protection from predation and increased reproductive fitness.