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A dendritic cell (DC) is an antigen-presenting cell (also known as an accessory cell) of the mammalian immune system. A DC's main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and adaptive immune systems. [1]
This shows that the skin immune system is a highly dynamic environment that can be rapidly and specifically remodeled by certain commensals. [18] Finally, studying microbiota interactions and skin T cells can help to detect the cause of various diseases and possible cures for these.
Photomicrograph of a histological section of human skin prepared for direct immunofluorescence using an anti-IgG antibody. The skin is from a patient with systemic lupus erythematosus and shows IgG deposit at two different places: The first is a band-like deposit along the epidermal basement membrane ("lupus band test" is
The immune system is involved in many aspects of physiological regulation in the body. The immune system interacts intimately with other systems, such as the endocrine [83] [84] and the nervous [85] [86] [87] systems. The immune system also plays a crucial role in embryogenesis (development of the embryo), as well as in tissue repair and ...
Immune electron microscopy (more often called immunoelectron microscopy) is the equivalent of immunofluorescence, but it uses electron microscopy rather than light microscopy. [1] Immunoelectron microscopy identifies and localizes a molecule of interest, specifically a protein of interest, by attaching it to a particular antibody .
Dermal macrophages belong to the mononuclear phagocyte system that serves a vital role in the innate immunity of the skin. [5] They are also a type of antigen-presenting cells (APCs) that can mediate the infiltration of immune cells during an immune response, suggesting dermal macrophages' influence on both the innate and adaptive immune systems.
Sentinel cells refer to cells in the body's first line of defense, which embed themselves in tissues such as skin. [1] Sentinel cells represent diverse array of cell types with the capability to monitor the presence of exogenous or potentially harmful particles and play a crucial role in recognizing and sampling signs of infection or abnormal cellular activity and/or death.
Micrograph of keratinocytes, basal cells and melanocytes in the epidermis Keratinocytes (stained green) in the skin of a mouse. Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells. [1]