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Double-muscled cattle are breeds of cattle that carry one of seven known mutations that limits and reduces the activity of the myostatin protein. Normally, myostatin limits the number of muscle fibers present at birth, and interfering with activity of this protein causes animals to be born with higher numbers of muscle fibers, consequently augmenting muscle growth.
Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. [6] Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth. [7] Myostatin is a secreted growth differentiation factor that is a member of the TGF beta ...
Myostatin inhibitors are a class of drugs that work by blocking the effect of myostatin, which inhibits muscle growth. In animal models and limited human studies, myostatin inhibitors have increased muscle size. They are being developed to treat obesity, sarcopenia, muscular dystrophy, and other illnesses.
The active-myostatin gene acts as a "governor" on muscle growth; myostatin is a protein that instructs muscles to stop growing. In effect, when inactive, as it is with Piedmontese cattle, it no longer prevents muscle development which is what allows for the hypertrophic condition sometimes referred to as "double muscling". [7]
The Belgian Blue has a natural mutation in the myostatin gene which codes for the protein, myostatin ("myo" meaning muscle and "statin" meaning stop). [7] Myostatin is a protein that inhibits muscle development. This mutation also interferes with fat deposition, resulting in very lean meat. [7]
Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. [1] Affected individuals have up to twice the usual amount of muscle mass in their bodies, but increases in muscle strength are not usually congruent. [ 2 ]
Prior to registration or recording, DNA testing is required to confirm the animal carries at least 1 copy of the Piedmontese-specific myostatin gene. [E] Naturalean animals that are DNA tested heterozygous (1-copy) are not registered, rather they are issued a registration number with the prefix "recorded". The 0-copy (non-carriers) cattle are ...
Nutritional Muscular Dystrophy (Nutritional Myopathy or White Muscle Disease) is a disease caused by a deficiency of selenium and vitamin E in dietary intake. [1] Soils that contains low levels of selenium produce forages and grains that are deficient in selenium.
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