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The cervical loop is the location on an enamel organ in a developing tooth where the outer enamel epithelium and the inner enamel epithelium join. The cervical loop is a histologic term indicating a specific epithelial structure at the apical side of the tooth germ, consisting of loosely aggregated stellate reticulum in the center surrounded by ...
The outer enamel epithelium, also known as the external enamel epithelium, is a layer of cuboidal cells located on the periphery of the enamel organ in a developing tooth. This layer is first seen during the bell stage. The rim of the enamel organ, where the outer and inner enamel epithelium join is called the cervical loop.
The Hertwig epithelial root sheath (HERS) or epithelial root sheath is a proliferation of epithelial cells located at the cervical loop of the enamel organ in a developing tooth. Hertwig epithelial root sheath initiates the formation of dentin in the root of a tooth by causing the differentiation of odontoblasts from the dental papilla.
The location where the outer enamel epithelium and inner enamel epithelium join is called the cervical loop. [1] The growth of cervical loop cells into the deeper tissues forms Hertwig Epithelial Root Sheath, which determines the root shape of the tooth. During tooth development there are strong similarities between keratinization and amelogenesis.
This layer is first seen during the cap stage, in which these inner enamel epithelium cells are pre-ameloblast cells. These will differentiate into ameloblasts which are responsible for secretion of enamel during tooth development. The location of the enamel organ where the outer and inner enamel epithelium join is called the cervical loop.
When follistatin, a BMP inhibitor, is over expressed in the epithelium of developing teeth, the ameloblasts do not differentiate and no enamel forms. Another example includes the conditional deletion of dicer-1 in the epithelium of developing teeth, which may cause impaired differentiation of ameloblasts resulting in deficient enamel formation.
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