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2. Methotrexate - Wikipedia

   en.wikipedia.org/wiki/Methotrexate

   Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents.It is effective for the treatment of several cancers, including solid tumours of breast, head and neck, lung, bladder, as well as acute lymphocytic leukemias, non-Hodgkin's lymphoma, osteosarcoma, and choriocarcinoma and other trophoblastic neoplasms.

3. Metronomic therapy - Wikipedia

   en.wikipedia.org/wiki/Metronomic_therapy

   In conventional chemotherapy, a dose close to the maximum tolerated dose is administered in a bolus manner to achieve cytotoxic effects on tumor cells. [5] However, the side effects are often significant as the cytotoxic agents also kill the fast-dividing cells normally present in the body, such as bone marrow cells and epithelial cells of the gastrointestinal tract. [6]

4. Folate deficiency - Wikipedia

   en.wikipedia.org/wiki/Folate_deficiency

   Methotrexate inhibits cell division and is particularly toxic to fast dividing cells, such as rapidly dividing cancer cells and the progenitor cells of the immune system. Folate supplementation is beneficial in patients being treated with long-term, low-dose methotrexate for inflammatory conditions, such as rheumatoid arthritis (RA) or ...

5. Talk:Methotrexate - Wikipedia

   en.wikipedia.org/wiki/Talk:Methotrexate

   Methotrexate inhibits Folic Acid reductase which is responsible for the conversion of Folic Acid to tetrahydrofolic acid. At two stages in the biosynthesis of ppurins and at one stage in the synthesis of Pyrimidines, one-carbon transfer reactions occur which require specific coenzymes synthesized in the cell from tetrahydrofolic acid.

6. Paul Ridker - Wikipedia

   en.wikipedia.org/wiki/Paul_Ridker

   [16] [17] In contrast, the federally funded CIRT (Cardiovascular Inflammation Reduction Trial) showed no benefit to low-dose Methotrexate but also no evidence of lowering Interleukin-1b, Interleukin-6 nor CRP. Thus, the positive CANTOS trial and the informative null CIRT trial defined the need to reduce signaling from the NLRP3 to Interleukin-1 ...

7. Disease-modifying antirheumatic drug - Wikipedia

   en.wikipedia.org/wiki/Disease-modifying_anti...

   Combinations of DMARDs are often used, because each drug in the combination can be used in a smaller dose than if it were given alone, thus reducing the risk of side effects. [citation needed] Many patients receive an NSAID and at least one DMARD, sometimes with low-dose oral glucocorticoids. If disease remission is observed, regular NSAIDs or ...

8. Escitalopram (Lexapro): Everything You Need to Know Before ...

   www.aol.com/escitalopram-lexapro-everything-know...

   Based on your symptoms and individual response to the medication, your provider will decide the correct dose of escitalopram for you — and may adjust your dosage of escitalopram over time.

9. List of drugs known for off-label use - Wikipedia

   en.wikipedia.org/wiki/List_of_drugs_known_for...

   Low-dose naltrexone is cheap without side effects and used to treat cancer and autoimmune diseases like focal segmental glomerulosclerosis. Naltrexone (Revia) for behavioral addiction: there is some belief that low-dose naltrexone may benefit the treatment of cancer, HIV, and multiple sclerosis by “normalizing” the immune system; however ...