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The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s. [25] [26] [27] Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway. They are given in a one-to-five ratio in their tablet ...
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. [1] Other uses include for middle ear infections and travelers' diarrhea. [1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. [1] [2] It is taken orally (swallowed by mouth). [1]
bedinvetmab - nerve growth factor inhibitor monoclonal antibody used for osteoarthritis in dogs; benazepril – ACE-inhibitor used in heart failure, hypertension, chronic kidney failure and protein-losing nephropathy
Certain sulfonamides (sulfadiazine or sulfamethoxazole) are sometimes mixed with the drug trimethoprim, which acts against dihydrofolate reductase. As of 2013, the Republic of Ireland is the largest exporter worldwide of sulfonamides, accounting for approximately 32% of total exports. [16]
Megaloblastic anaemia; Methaemoglobinaemia; Erythema multiforme; Low blood sugar; Hepatitis (liver swelling); Crystalluria (crystals in the urine); Urinary obstruction causing difficulty passing urine
Sulfadimethoxine (or sulphadimethoxine, trade names Di-Methox or Albon) is a long-lasting sulfonamide antimicrobial medication used in veterinary medicine. It is used to treat many infections, including respiratory, urinary tract, enteric, and soft tissue infections [3] and can be given as a standalone or combined with ormetoprim to broaden the target range. [2]
Sulfamethoxazole is primarily renally excreted via glomerular filtration and tubular secretion. [8] About 20% of the sulfamethoxazole in urine is the unchanged drug, about 15–20% is the N-glucuronide conjugate, and about 50–70 % is the acetylated metabolite. [11] Sulfamethoxazole is also excreted in human milk. [8]
When the risk of anaerobic infection is high, as with intra-abdominal and post-surgical infections, proper antimicrobial prophylaxis may reduce the risk. Therapy with antimicrobials (e.g., aminoglycosides, trimethoprim-sulfamethoxazole, older quinolones) often does not eradicate anaerobes. [citation needed]
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