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The first medical use of fumaric acid was described in 1959 by Walter Schweckendiek, a German chemist, [15] and was a topical formulation for psoriasis. The Swiss company Fumapharm eventually brought Fumaderm, an oral formulation of dimethyl fumarate (along with some monoesters) to market for psoriasis in Germany in 1994.
Three generic immunomodulators: Glatiramer acetate (Copaxone, injection) Teriflunomide (Aubagio), [2] Monomethyl fumarate itself and its two precursors, which alters the NRF2 (nuclear factor erythroid 2(NF-E2)-related factor 2) transcription factor: Dimethyl fumarate (Tecfidera), [3] [4] Diroximel fumarate (Vumerity), [5] approved by the FDA in ...
New TECFIDERA ® (Dimethyl Fumarate) Data Show Sustained Efficacy and Long-Term Safety in a Broad Range of Multiple Sclerosis Patients - Interim Results from ENDORSE Extension Study Reinforce ...
The article US Patent Office Grants Patent Claiming Dosing Regimen for TECFIDERA™ (Dimethyl Fumarate) originally appeared on Fool.com. Try any of our Foolish newsletter services free for 30 days .
CHMP Issues Positive Opinion for TECFIDERA ™ (Dimethyl Fumarate) as a First-Line Treatment for Multiple Sclerosis in the European Union -European Commission Decision Anticipated In Second ...
Dimethyl fumarate, marketed as Tecfidera by Biogen Idec, was approved by the Food and Drug Administration in March 2013 following the conclusion of a Phase III clinical trial which demonstrated that the drug reduced relapse rates and increased time to progression of disability in people with multiple sclerosis. [6]
[16] [40] In 2013 one further oral drug, dimethyl fumarate -or BG12- (which is an improved version of fumaric acid, an already existing drug), was approved by the FDA. Another oral drug, cladribine, was approved in Russia and Australia in 2010. Its application was rejected by the FDA and EMEA in 2011, due to safety concerns.
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