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Pembrolizumab, sold under the brand name Keytruda, is a humanized antibody, more specifically a PD-1 inhibitor, used in cancer immunotherapy that treats melanoma, lung cancer, head and neck cancer, Hodgkin lymphoma, stomach cancer, cervical cancer, and certain types of breast cancer. [12] [14] [15] [16] It is administered by slow intravenous ...
The most common kidney related changes are acute interstitial nephritis, followed by glomerular diseases and then tubular damage. [43] The detailed mechanism of these adverse effects are not fully elucidated; [ 44 ] however, they are clearly different from known autoimmune diseases. [ 45 ]
The most common side effects reported while taking this medication during a trial were dyspnea, asthenia, fatigue, and nausea. [26] Symptoms of overdose are similar to the side effect profile of the medication, so it could involve significant immune-mediated reactions. [27]
Common side effects include fever, infection, cough, headache, trouble sleeping, and rash. [143] Other severe side effects include heart failure, allergic reactions, and lung disease. [143] Use during pregnancy may harm the baby. [136] Trastuzumab works by binding to the HER2 receptor and slowing down cell replication. [143]
Keytruda sales rose 21% to $6.6 billion as the company was able to increase use of the drug in earlier stage cancers, topping analyst forecasts of $6.5 billion.
Pembrolizumab (brand name Keytruda) is another PD-1 inhibitor that was approved by the FDA in 2014 and was the second checkpoint inhibitor approved in the United States. [17] Keytruda is approved to treat melanoma and lung cancer and is produced by Merck .
Side effects were similar to the second dose: headache, fatigue, and injection site pain. A booster shot of Moderna's coronavirus vaccine has similar side effects to what people experienced after ...
reduction of side effects of cardiac surgery: Pidilizumab [40] mab: humanized: PD-1: cancer and infectious diseases Pinatuzumab vedotin [40] mab: humanized: CD22: cancer Pintumomab: mab: mouse: adenocarcinoma antigen: adenocarcinoma (imaging) Placulumab [15] mab: human: TNF: pain and inflammatory diseases Pozelimab [35] Veopoz: mab: human: C5 ...
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