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Cryptococcosis is a potentially fatal fungal infection of mainly the lungs, presenting as a pneumonia, and in the brain, where it appears as a meningitis. [4] [9] Coughing, difficulty breathing, chest pain and fever are seen when the lungs are infected. [5]
The current treatment options for cryptococcosis are not optimal for treatment. [3] AmB is highly toxic to humans, and both fluconazole and flucytosine have been shown to cause development of drug resistanse in C. neoformans. A recent study from 2024 suggested brilacidin as an alternative treatment option. [34]
Cryptococcus neoformans is cosmopolitan and is the most prominent medically important species. It is best known for causing a severe form of meningitis and meningoencephalitis in people with HIV/AIDS. It may also infect organ-transplant recipients and people receiving certain cancer treatments. [9]
Cryptococcus gattii, formerly known as Cryptococcus neoformans var. gattii, is an encapsulated yeast found primarily in tropical and subtropical climates. Its teleomorph is Filobasidiella bacillispora, a filamentous fungus belonging to the class Tremellomycetes.
The majority of Cryptococcus species live in the soil and do not cause disease in humans. Cryptococcus neoformans is the major human and animal pathogen. Papiliotrema laurentii and Naganishia albida, both formerly referred to Cryptococcus, have been known to occasionally cause moderate-to-severe disease in human patients with compromised immunity.
Treatment is generally performed using antifungal medicines, usually in the form of a cream or by mouth or injection, depending on the specific infection and its extent. [15] Some require surgically cutting out infected tissue. [3] Fungal infections have a world-wide distribution and are common, affecting more than one billion people every year ...
By RYAN GORMAN Horrifying video has emerged of doctors pulling maggots out of a man's ear. The unidentified Indian man went to a doctor's office to complain about hearing a non-stop buzzing sound.
An outbreak of Cryptosporidium hominis occurs in the southern part of Milwaukee, Wisconsin, and kills 101 people, caused by human feces contaminating the city's water system and evaded the water treatment as the cysts survive chlorine. An elderly delivery man in Dallas, Texas comes down with leishmaniasis.