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Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity ...
Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
Sadaf Farooqi has fundamentally altered our understanding of human obesity. Her work was key to the discovery of the first mutations that cause human obesity, defining and characterising a range of previously undescribed genetic obesity syndromes, and establishing that the principal driver of obesity in these monogenic syndromes was a failure ...
Pathophysiology of obesity is the study of disordered physiological processes that cause, result from, or are otherwise associated with obesity. A number of possible pathophysiological mechanisms have been identified which may contribute in the development and maintenance of obesity.
17202 Ensembl ENSG00000166603 ENSMUSG00000047259 UniProt P32245 P56450 RefSeq (mRNA) NM_005912 NM_016977 RefSeq (protein) NP_005903 NP_058673 Location (UCSC) Chr 18: 60.37 – 60.37 Mb Chr 18: 66.99 – 66.99 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Melanocortin 4 receptor (MC 4 R) is a melanocortin receptor that in humans is encoded by the MC4R gene. It encodes the MC 4 R ...
Human genetic variation is the genetic differences in and among ... For the monogenic diseases, ... (Gower et al. 2003), obesity (Fernandez et al. 2003), and ...
The review of global studies revealed that the prevalence of obesity increased by 150% in the period covering 2012–2023 compared to 2000–2011, indicating that pediatric obesity and overweight ...
Mendelian traits behave according to the model of monogenic or simple gene inheritance in which one gene corresponds to one trait. Discrete traits (as opposed to continuously varying traits such as height) with simple Mendelian inheritance patterns are relatively rare in nature, and many of the clearest examples in humans cause disorders.