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The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...
The third-generation iPhone SE (also known as the iPhone SE 3 or the iPhone SE 2022) is a smartphone designed and developed by Apple Inc. It is part of the 15th generation of the iPhone, alongside the iPhone 13 and 13 Mini and iPhone 13 Pro and 13 Pro Max models. Apple announced the third-generation iPhone SE on March 8, 2022, as the successor ...
The second-generation iPhone SE (also known as the iPhone SE 2 or the iPhone SE 2020) is a smartphone designed, developed, and marketed by Apple Inc. It is part of the 13th generation of the iPhone, alongside the iPhone 11 and 11 Pro/Pro Max models. Apple announced it on April 15, 2020, coinciding with the discontinuation of the iPhone 8 and 8 ...
The difference between first- and second-generation antipsychotics is a subject of debate. The second-generation antipsychotics are generally distinguishable by the presence of 5HT2A receptor antagonism and a corresponding lower propensity for extrapyramidal side effects compared to first-generation antipsychotics. [15]
The second-generation antipsychotic olanzapine is thought to have a rebound-induced hyperthermia, which may be mediated by serotonin receptors. [8] Hyperthermia, or elevated core body temperature, is associated with neuroleptic malignant syndrome, a potentially lethal syndrome that commonly occurs due to excessive D2R antagonism. [9] [note 1]
Clozapine is a psychiatric medication and was the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
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