Search results
Results from the WOW.Com Content Network
Pregabalin, sold under the brand name Lyrica among others, is an anticonvulsant, analgesic, and anxiolytic amino acid medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless legs syndrome, opioid withdrawal, and generalized anxiety disorder (GAD). [13] [17] [18] Pregabalin also has antiallodynic properties.
However, food has been found to substantially delay the absorption of pregabalin and to significantly reduce peak levels without affecting the bioavailability of the drug; T max values for pregabalin of 0.6 hours in a fasted state and 3.2 hours in a fed state (5-fold difference), and the C max is reduced by 25–31% in a fed versus fasted state ...
However these drugs are still of relatively low potency, and scientists have struggled for years to come up with an improvement on pregabalin, with increasing pressure to find a suitably improved replacement before the patent on pregabalin expired in 2018. [1]
A new FDA-approved treatment for high blood pressure targeting the nerves of the kidneys has been studied in Austin and is now being done at the Heart Hospital of Austin. On March 27, the hospital ...
Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke, heart failure, kidney failure and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21%, and can reduce the likelihood of dementia ...
Phenibut is a GABA B receptor agonist, [42] as well as an antagonist at α 2 δ subunit-containing voltage-dependent calcium channels (VDCCs), similarly to gabapentinoids like gabapentin and pregabalin. [44] The medication is not approved by the FDA for use in the United States, but is sold online as a supplement. [45] [46]
Gabapentin concentration in cerebrospinal fluid is approximately 9–14% of its blood plasma concentration. [93] Due to its low lipophilicity, [93] gabapentin requires active transport across the blood–brain barrier. [94] [84] [95] [96] The LAT1 is highly expressed at the blood–brain barrier [97] and transports gabapentin across into the brain.
The results of these studies prompted public health campaigns to increase public awareness of hypertension and promoted the measurement and treatment of high blood pressure. These measures appear to have contributed at least in part to the observed 50% fall in stroke and ischemic heart disease between 1972 and 1994.