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The uncertainty and variability in the dose–response relationship of dioxins in terms of their toxicity, as well as the ability of dioxins to bioaccumulate, have led WHO experts to recommending very low tolerable daily intake (TDI) of dioxin, 1-4 pg/kg body weight per day, i.e. 7x10 −11 to 2.8x10 −10 g per 70-kg person per day, to allow ...
In clinical studies, metadoxine has been reported to reduce the half-life of ethanol in healthy volunteers and in acutely intoxicated patients; to accelerate the metabolism of alcohol and acetaldehyde into less toxic higher ketones and to improve their urinary clearance; to restore laboratory variables such as alcohol, ammonia, γ-GT, and alanine aminotransferase; and to improve clinical ...
However, there has been some uncertainty on the causal link between Agent Orange/dioxin exposure. In 2006, a meta-analysis indicated large amount of heterogeneity between studies and emphasized a lack of consensus on the issue. [15] Stillbirths, cleft palate, and neural tube defects, with spina bifida were the most statistically significant ...
They are commonly but inaccurately referred to as dioxins for simplicity, because every PCDD molecule contains a dibenzo-1,4-dioxin skeletal structure, with 1,4-dioxin as the central ring. Members of the PCDD family bioaccumulate in humans and wildlife because of their lipophilic properties, and may cause developmental disturbances and cancer .
Dibenzo-1,4-dioxin, also known as dibenzodioxin or dibenzo-p-dioxin (molecular formula C 12 H 8 O 2), in which two benzene rings are connected through two oxygen atoms. That is the parent compound of the dioxins (see next in which the dioxins comprise a key part of the class).
Congener descriptors give a shorthand notation for geometry and substituent positions. The twelve congeners that display all four of the descriptors are referred to as being "dioxin-like", referring both to their toxicity and structural features which make them similar to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2378-TCDD). [1]
meta-Phenylenediamine; para-Phenylenediamine; N-Phenyl-2-naphthylamine; ortho-Phenylphenol; Picene; Picloram; β-Picoline; Piperonyl butoxide; Polyacrylic acid; Polychlorinated dibenzo-p-dioxins (other than 2,3,7,8-tetrachlorodibenzo-p-dioxin) Polychlorinated dibenzofurans; Polychloroprene; Polyethylene; Polymethylene polyphenyl isocyanate ...
Emigrants to the city and even children born after the end of the Agent Orange spraying operations had blood samples indicating a presence of dioxin (Schecter et al., 2001). [9] Meta-studies have affirmed the dioxin pathway of genetic inheritance, e.g. a statistically significant correlation between paternal exposure to Agent Orange and spina ...