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The hormonal effects of quercetin found in animal studies raise the suspicion of a parallel effect in humans, particularly in respect of estrogen-dependent tumors. [38] Quercetin supplementation can interfere with the effects of medications. The precise nature of this interaction is known for some common medicines, but for many, it is not. [38]
Quercetin is an antioxidant that may reduce your risk of certain diseases. We consulted research and registered dietitians to explain the benefits, how to add it to your diet, and the side effects ...
Quercetin might also help individuals manage conditions like high blood pressure or allergies, Dr. Cederquist says. But, it’s always best to talk to your doctor first. Quercetin Side Effects
Quercetin, a flavonoid from fruits and leaves, acts like curcumin and piperine. It increases the bioavailability of the active agent paclitaxel used to treat cancer. Carum carvi, a herb from Apiaceae enhances the bioavailability of anti tuberculosis drugs such as rifampicin, isoniazid, and pyrazinamide. [24]
Therefore, bioavailability for dietary supplements can be defined as the proportion of the administered substance capable of being absorbed and available for use or storage. [11] In both pharmacology and nutrition sciences, bioavailability is measured by calculating the area under curve (AUC) of the drug concentration time profile.
Adverse effects of polyphenol intake range from mild (e.g., gastrointestinal tract symptoms) [2] to severe (e.g., hemolytic anemia or hepatotoxicity). [83] In 1988, hemolytic anemia following polyphenol consumption was documented, resulting in the withdrawal of a catechin -containing drug. [ 84 ]
Rutin (rutoside, quercetin-3-O-rutinoside or sophorin) is the glycoside combining the flavonol quercetin and the disaccharide rutinose (α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranose). It is a flavonoid glycoside found in a wide variety of plants, including citrus .
Equol is a compound that can exist in two mirror-image forms known as enantiomers: (S)-equol and (R)-equol.(S)-equol is produced in humans and animals with the ability to metabolize the soy isoflavone daidzein, while (R)-equol can be chemically synthesized. [9]
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