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2. Enfortumab vedotin - Wikipedia

   en.wikipedia.org/wiki/Enfortumab_vedotin

   Enfortumab vedotin, sold under the brand name Padcev, is an antibody-drug conjugate [6] used for the treatment of urothelial cancer. [4] [7] It is a nectin-4-directed antibody and microtubule inhibitor conjugate. [4] [7] Enfortumab refers to the monoclonal antibody part, and vedotin refers to the payload drug (MMAE) and the linker. [5]

3. Seagen's (SGEN) MAA for Enfortumab Vedotin Gets EMA ... - AOL

   www.aol.com/news/seagens-sgen-maa-enfortumab...

   The European Medicines Agency accepts Seagen (SGEN) and Astellas Pharma's marketing application for enfortumab vedotin for treating adult patients with advanced/metastatic urothelial cancer.

4. Seattle Genetics' Enfortumab Vedotin BLA Gets Priority Review

   www.aol.com/news/seattle-genetics-enfortumab...

   The FDA accepts Seattle Genetics (SGEN) and Astellas' BLA for enfortumab vedotin under a priority review to treat advanced/metastatic urothelial cancer. A verdict is pending on Mar 15, 2020.

5. Antibody–drug conjugate - Wikipedia

   en.wikipedia.org/wiki/Antibody–drug_conjugate

   Polatuzumab vedotin: Polivy Genentech, Roche relapsed or refractory diffuse large B-cell lymphoma (DLBCL) [24] Enfortumab vedotin: Padcev Astellas/Seattle Genetics: adult patients with locally advanced or metastatic urothelial cancer who have received a PD-1 or PD-L1 inhibitor, and a Pt-containing therapy [25] Trastuzumab deruxtecan: Enhertu

6. Nectin - Wikipedia

   en.wikipedia.org/wiki/Nectin

   Nectin-4 : Enfortumab vedotin-ejfv was approved by the FDA in 2019; it is a Nectin-4-directed antibody drug conjugate that has shown clinical activity in metastatic urothelial cancer. [ 7 ] References

7. Trump's tariffs on China bite US bargain-hunting online shoppers

   www.aol.com/news/trumps-tariffs-china-bite-us...

   On Wednesday, Matthew Cannon's college-age daughter forwarded him a request from delivery company DHL asking for duties and fees of $45.19 tied to her order from Australian fashion seller I.Am.Gia ...

8. Monomethyl auristatin E - Wikipedia

   en.wikipedia.org/wiki/Monomethyl_auristatin_E

   Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism.

9. File:Enfortumab vedotin.svg - Wikipedia

   en.wikipedia.org/wiki/File:Enfortumab_vedotin.svg

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