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Brotizolam [3] (marketed under brand name Lendormin) is a sedative-hypnotic [4] thienotriazolodiazepine [5] drug which is a benzodiazepine analog. [6] It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties, and is considered to be similar in effect to other short-acting hypnotic benzodiazepines such as triazolam or midazolam. [7]
Common side effects include diarrhea, constipation, headache, sleepiness, and itchiness. [8] Serious side effects include QT prolongation and severe allergic reaction. [8] It appears to be safe during pregnancy but has not been well studied in this group. [8] It is a serotonin 5-HT 3 receptor antagonist. [8]
Cinnarizine's antagonistic effects of D2 dopamine receptors in the striatum leads to symptoms of depression, tremor, muscle rigidity, tardive dyskinesia, and akathisia. 17 of 100 new parkinsonism cases are linked to administration of either cinnarizine or flunarizine. [5] Drug induced parkinsonism is the second leading cause of parkinsonism. [22]
Chemical structure of the prototypical Z-drug zolpidem. Nonbenzodiazepines (/ ˌ n ɒ n ˌ b ɛ n z oʊ d aɪ ˈ æ z ɪ p iː n,-ˈ eɪ-/ [1] [2]), sometimes referred to colloquially as Z-drugs (as many of their names begin with the letter "z"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses, such as for treating insomnia [3 ...
Both newer and older drugs are generally equally effective in new onset epilepsy. [42] The newer drugs tend to have fewer side effects. [42] For newly diagnosed partial or mixed seizures, there is evidence for using gabapentin, lamotrigine, oxcarbazepine or topiramate as monotherapy. [42]
Common side effects of this medication include upset stomach, nausea, constipation, diarrhea, runny nose, sore throat, headache, and dizziness. More serious complications may include inflammation ...
Due to the possibility of unblinding by side effects, it was unclear whether TCAs had a genuine antidepressant effect or whether the benefits were merely due to amplified placebo effects. [11] TCAs had a higher rate of serious adverse effects than placebo, but this did not reach statistical significance ( OR Tooltip odds ratio = 2.78; 95% CI: 2 ...
Doses of 25 mg were found safe and well tolerated for 52 weeks. [7] When given concomitantly with opioid analgesics, naloxegol reduced constipation-related side effects, while maintaining comparable levels of analgesia. [8] The most common side effects are abdominal pain, diarrhea, nausea, flatulence, vomiting, and headache. [9]