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The liver span is a measurement performed during physical examination to determine the size of the liver and identify possible hepatomegaly.. It is the distance between the lower border of the liver in the mid-clavicular line obtained by palpation, and the upper border of the liver in the mid-clavicular line detected by percussion (the upper border of the liver lies behind the ribs and can not ...
Liver function tests (LFTs or LFs), also referred to as a hepatic panel or liver panel, are groups of blood tests that provide information about the state of a patient's liver. [1] These tests include prothrombin time (PT/INR), activated partial thromboplastin time (aPTT), albumin , bilirubin (direct and indirect), and others.
There is considerable size variation between individuals, with the standard reference range for men being 970–1,860 grams (2.14–4.10 lb) [13] and for women 600–1,770 g (1.32–3.90 lb). [14] It is both the heaviest internal organ and the largest gland in the human body.
Abdominal ultrasonography of the liver, as a sagittal plane through the midclavicular line, with some standard measurements [2] Right lobe of the liver at the midclavicular line at ages 0 to 7 [16] Suspicion of hepatomegaly indicates a thorough medical history and physical examination, wherein the latter typically includes an increased liver span.
The liver scratch test can be used when other exam techniques used to approximate liver size are ineffective or unavailable [2] and is thought to be most useful if the abdomen is distended, too tender for direct palpation, the abdominal muscles are too rigid, or the patient is obese. [3]
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The proportion of AST to ALT in hepatocytes is about 2.5:1, but because AST is removed from serum by the liver sinusoidal cells twice as quickly (serum half-life t 1/2 = 18 hr) compared to ALT (t 1/2 = 36 hr), so the resulting serum levels of AST and ALT are about equal in healthy individuals, resulting in a normal AST/ALT ratio around 1.
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