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Validol, the anxiety medication containing a roughly 25% solution of menthol in menthyl isovalerate is prepared essentially in one step, in which the amount of menthol added before conducting the acid catalysed esterification is in an excess such that the resulting solution of the yielded ester has around 25% menthol, simplifying the procedure.
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For many people, menthol produces a cooling sensation when inhaled, eaten, or applied to the skin, and mint plants have been used for centuries for topical pain relief and as a food flavoring. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation .
Topical counter-irritants are non-analgesic, non-anesthetic substances or treatments used to treat pain. Capsaicin, menthol (mint oil), methyl salicylate, and camphor are examples of counterirritants. Heat and cold therapy and massage relieve pain by counterstimulation. [citation needed]
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