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A number of drugs that cause QT prolongation does not directly block hERG, but reduces the trafficking of the mature protein to the surface of the cell. This includes probucol , which appears to enhance the intercellular degradation of hERG; and several cardiac glycosides , which reduces trafficking due to decreased intracellular potassium.
The most common medications that cause priapism are intra-cavernous injections for the treatment of erectile dysfunction (papaverine, alprostadil). Other medication groups reported are antihypertensives (e.g. Doxazosin ), antipsychotics (e.g., chlorpromazine , clozapine ), antidepressants (most notably trazodone ), anti-convulsant and mood ...
Priapism is a non-intimate prolonged arousal that isn’t relieved by climax. It is a serious medical emergency that can cause pain, lasting damage to the privates and permanent dysfunction if it ...
[1] [2] [3] Alprostadil is a prostaglandin vasodilator that allows more blood to flow into the area by relaxing the smooth muscle in the blood vessels of the penis. [ 3 ] [ 7 ] Papaverine is a smooth muscle relaxant that acts by increasing blood flow to the penis.
Erectile dysfunction can cause a “self-perpetuating cycle of anxiety and performance pressure,” says one expert. (Photo illustration: Victoria Ellis for Yahoo News; photo: ...
Topiramate can cause birth defects, including cleft lip and palate. [12] Risks/benefits should be carefully discussed with the full treatment team. Topiramate is considered "probably compatible" with lactation and is not contraindicated for breastfeeding, though monitoring of the infant for diarrhea or poor weight gain may be considered.
Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval. [7] It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. [1]
Sexual dysfunction is especially common among people who have anxiety disorders. [2] [30] [31] [5] Ordinary anxiety can cause erectile dysfunction in men without psychiatric problems, but clinically diagnosable disorders such as panic disorder commonly cause avoidance of intercourse and premature ejaculation. [32]