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The vestibular system's semicircular canal – a cross-section. This is the site of cinnarizine's anti-vertigo action. It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus by limiting the activity of the vestibular hair cells which send signals about ...
"Treatment of vertigo due to acute unilateral vestibular loss with a fixed combination of cinnarizine and dimenhydrinate: a double-blind, randomized, parallel-group clinical study". Clin Ther . 26 (6): 866– 77.
Cinnarizine (also used for motion sickness and vertigo) Clemastine; Clomipramine (tricyclic antidepressant) Clozapine (atypical antipsychotic; trade name: Clozaril) Cyclizine; Cyproheptadine; Desloratadine; Dexbrompheniramine; Dexchlorpheniramine; Dimenhydrinate (used as an antiemetic and for motion sickness) Dimetindene; Diphenhydramine (Benadryl)
Cyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo. [2] It may also be used for nausea after general anaesthesia or that which developed from opioid use. [2] [3] It is taken by mouth, in the rectum, or injected into a vein. [3] [4]
Symptomatic treatment with antihistaminics such as cinnarizine, however, can be used to suppress the symptoms of vestibular neuritis while it spontaneously regresses. [27] Prochlorperazine is another commonly prescribed medication to help alleviate the symptoms of vertigo and nausea.
Meclizine is effective in inhibiting nausea, vomiting, and dizziness caused by motion sickness. [10] The drug is safe for treating nausea in pregnancy and is a first-line therapy for this use. [11] [12] Meclizine may not be strong enough for especially sickening motion stimuli, and second-line defenses should be tried in those cases. [13]
Flunarizine is a selective calcium antagonist with moderate other actions including antihistamine, serotonin receptor blocking and dopamine D 2 blocking activity. Compared to other calcium channel blockers such as dihydropyridine derivatives, verapamil and diltiazem, flunarizine has low affinity to voltage-dependent calcium channels.
An H 3 receptor antagonist is a type of antihistaminic drug used to block the action of histamine at H 3 receptors.. Unlike the H 1 and H 2 receptors which have primarily peripheral actions, but cause sedation if they are blocked in the brain, H 3 receptors are primarily found in the brain and are inhibitory autoreceptors located on histaminergic nerve terminals, which modulate the release of ...
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