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The Vi capsular polysaccharide vaccine (or ViCPS) is a typhoid vaccine recommended by the World Health Organization for the prevention of typhoid (another is Ty21a).The vaccine was first licensed in the US in 1994 and is made from the purified Vi capsular polysaccharide from the Ty2 Salmonella Typhi strain; it is a subunit vaccine.
[1] [2] [3] Several types are widely available: typhoid conjugate vaccine (TCV), Ty21a (a live oral vaccine) and Vi capsular polysaccharide vaccine (ViPS) (an injectable subunit vaccine). They are about 30 to 70% effective in the first two years, depending on the specific vaccine in question. The Vi-rEPA vaccine is efficacious in children. [4]
Ty21a is a live attenuated bacterial vaccine that protects against typhoid.First licensed in Europe in 1983 and in the United States in 1989, it is an orally administered, live-attenuated Ty2 strain of S. Typhi in which multiple genes, including the genes responsible for the production of Vi, have been deleted so as to render it harmless but nevertheless immunogenic.
Vi capsular polysaccharide vaccine (ViCPS) against typhoid caused by the Typhi serotype of Salmonella enterica. [23] Instead of being a protein, the Vi antigen is a bacterial capsule polysacchide, made up of a long sugar chain linked to a lipid. [24] Capsular vaccines like ViCPS tend to be weak at eliciting immune responses in children.
In 1934, the discovery of the Vi capsular antigen by Arthur Felix and Miss S. R. Margaret Pitt enabled the development of the safer Vi Antigen vaccine – which is widely in use today. [118] Arthur Felix and Margaret Pitt also isolated the strain Ty2, which became the parent strain of Ty21a , the strain used as a live-attenuated vaccine for ...
A Subunit vaccine is a fragment of a pathogen, ... Vi capsular polysaccharide vaccine This page was last edited on 2 April 2021, at 05:09 (UTC). Text ...
P. EpiVacCorona; UB-612; NmVac4-A/C/Y/W-135; Pneumococcal polysaccharide vaccine; Vi capsular polysaccharide vaccine; CimaVax-EGF; RTS,S; Tecemotide; 202-CoV; Abdala ...
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