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77782 Ensembl ENSG00000051341 ENSMUSG00000034206 UniProt O75417 Q8CGS6 RefSeq (mRNA) NM_199420 NM_006596 NM_001159369 NM_029977 RefSeq (protein) NP_955452 NP_001152841 NP_084253 Location (UCSC) Chr 3: 121.43 – 121.55 Mb Chr 16: 36.83 – 36.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene. This ...
A biochemical assay system shows that at least 6 genes are required for microhomology-mediated end joining: FEN1, Ligase III, MRE11, NBS1, PARP1 and XRCC1. [9] All six of these genes are up-regulated in one or more cancers. In humans, DNA polymerase theta, encoded by the POLQ gene, plays a central role in microhomology-mediated end joining. [7]
DNA polymerase II (also known as DNA Pol II or Pol II) is a prokaryotic DNA-dependent DNA polymerase encoded by the PolB gene. [1] DNA Polymerase II is an 89.9-kDa protein and is a member of the B family of DNA polymerases. It was originally isolated by Thomas Kornberg in 1970, and characterized over the next few years.
DNA polymerase's ability to slide along the DNA template allows increased processivity. There is a dramatic increase in processivity at the replication fork. This increase is facilitated by the DNA polymerase's association with proteins known as the sliding DNA clamp. The clamps are multiple protein subunits associated in the shape of a ring.
51426 27015 Ensembl ENSG00000122008 ENSMUSG00000021668 UniProt Q9UBT6 Q9QUG2 RefSeq (mRNA) NM_016218 NM_001345921 NM_001345922 NM_012048 RefSeq (protein) NP_001332850 NP_001332851 NP_057302 NP_057302.1 NP_001334531 NP_001334532 NP_001334533 NP_001334535 NP_036178 Location (UCSC) Chr 5: 75.51 – 75.6 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse DNA polymerase kappa is a DNA ...
Frequently used B-type DNA polymerases are the Pfu polymerase, [4] the Pwo polymerase, [17] the KOD polymerase, [3] the Tli polymerase (also called Vent), which originates from various archaea, [18] the Tag polymerase, [19] the Tce polymerase, [20] the Tgo polymerase, [8] the TNA1 polymerase, [21] the Tpe polymerase, [22] the Tthi polymerase ...
A specialized DNA polymerase called terminal deoxynucleotidyl transferase (TdT), which is only expressed in lymph tissue, adds nontemplated nucleotides to the ends before the break is joined. [ 35 ] [ 36 ] This process couples "variable" (V), "diversity" (D), and "joining" (J) regions, which when assembled together create the variable region of ...
This leads to an issue due to the fact that DNA polymerase is only able to add to the 3' end of the DNA strand. The 3'-5' action of DNA polymerase along the parent strand leaves a short single-stranded DNA (ssDNA) region at the 3' end of the parent strand when the Okazaki fragments have been repaired.
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