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[3] [4] [5] Manipulation of epigenetic alterations holds great promise for cancer prevention, detection, and therapy. [ 6 ] [ 7 ] In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as the silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone ...
Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
Oncogene received a 2023 impact factor of 6.9 and received Journal Citation Reports rankings of 18th out of 191 in the category Genetics & Heredity, 29th out of 205 in the category Cell Biology, 32nd out of 313 in the category Biochemistry & Molecular Biology, and 43rd out of 322 journals in the category Oncology. [3]
Molecular Cancer is a peer-reviewed open-access scientific journal covering all aspects of cancer research. The journal is published by BioMed Central and was established in 2002. The first editor-in-chief was Chi V. Dang, who is also the scientific director of the Ludwig Institute for Cancer Research . [ 1 ]
The journal publishes both full-length and mini-reviews, original research, meta-analysis, and results from clinical studies. In addition, the journal has published manuscripts focused on ethical and regulatory considerations of gene and cell therapy. As well as important regulatory, manufacturing, and logistical aspects of gene therapy research.
Individual differences in drug metabolism and response can be partially explained by epigenetic changes. [7] [8] Epigenetic changes in genes that encode drug targets, enzymes, or transport proteins that affect the body's ability to absorb, metabolize, distribute and excrete substances that are foreign to the body (Xenobiotics) can result in changes in one's toxicity levels and drug response.
Cancer Cell is internationally regarded as one of the top cancer research and oncology journals. According to the Journal Citation Reports, the 2022 impact factor of the journal is 50.3. It is part of the Cell Press portfolio, which is owned by Elsevier. Issues are published monthly in print and online versions.
In a study on the epigenetic effects of physical exercise on breast cancer in women, blood samples from breast cancer patients were collected before and after 6 months of moderate-intensity aerobic exercise. [28] The test group experienced 129 minutes of exercise on average per week compared to the control group’s 21.8 minutes a week.