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Malabsorption is a state arising from abnormality in absorption of food nutrients across the gastrointestinal (GI) tract. Impairment can be of single or multiple nutrients depending on the abnormality.
Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack or reduction of digestive enzymes made by the pancreas.EPI can occur in humans and is prevalent in many conditions [1] such as cystic fibrosis, [2] Shwachman–Diamond syndrome, [3] different types of pancreatitis, [4] multiple types of diabetes mellitus (Type 1 and Type 2 diabetes), [5] advanced ...
Malabsorption; Malaria (malignant tertian) Maldigestion; Malonyl-CoA decarboxylase deficiency; Maple syrup urine disease; Mcquarrie type infantile idiopathic hypoglycemia; Medium chain acyl-CoA dehydrogenase deficiency; Mesothelioma; Methylmalonic acidemia; Mitiglinide; Mitochondrial DNA depletion syndrome, hepatocerebral form
Malabsorption is the inability to absorb food fully, mostly from disorders in the small bowel, but also due to maldigestion from diseases of the pancreas. Causes include: [ citation needed ] enzyme deficiencies or mucosal abnormality , as in food allergy and food intolerance , e.g. celiac disease (gluten intolerance), lactose intolerance ...
Other tests include the (13)C-mixed triglycerides test and fecal elastase, to detect possible fat maldigestion due to exocrine pancreatic insufficiency, [14] or various specific tests to detect other causes of malabsorption such as celiac disease. [15]
Worldwide, around 65% of adults are affected by lactose malabsorption. [5] [8] Other mammals usually lose the ability to digest lactose after weaning. Lactose intolerance is the ancestral state of all humans before the recent evolution of lactase persistence in some cultures, which extends lactose tolerance into adulthood. [9]
Fructose malabsorption is a digestive disorder in which absorption of fructose is impaired by deficient fructose carriers in the small intestine's enterocytes. [citation needed] Three autosomal recessive disorders impair fructose metabolism in liver cells.
Treatment strategies should focus on identifying and correcting the root causes, where possible, resolving nutritional deficiencies, and administering antibiotics. This is especially important for patients with indigestion and malabsorption. [4] Although whether antibiotics should be a first line treatment is a matter of debate.