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In coeliac disease, anti-actin antibody levels correlate with the level of intestinal damage. [2] [3] In autoimmune hepatitis, anti-actin antibody levels correlate with patterns of immune recognition, [4] the pattern of recognition was specific to a small percentage of autoimmune hepatitis type 1 or cryptogenic hepatitis patients. [5]
Actin beta (HUGO Gene Nomenclature Committee abbreviation ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins [5] [6] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of ...
The cloned enzyme donor immunoassay (CEDIA) involves genetically engineering an enzyme (e.g., beta-galactosidase) into two inactive fragments: a small enzyme donor (ED) conjugated with the drug analog, and a larger enzyme acceptor (EA). When the two fragments associate, the full enzyme converts a substrate into a cleaved colored product.
Immunofluorescence is a widely used example of immunostaining (using antibodies to stain proteins) and is a specific example of immunohistochemistry (the use of the antibody-antigen relationship in tissues). This technique primarily utilizes fluorophores to visualize the location of the antibodies, while others provoke a color change in the ...
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. β-Catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene.
7114 n/a Ensembl ENSG00000205542 n/a UniProt P62328 n/a RefSeq (mRNA) NM_021109 n/a RefSeq (protein) NP_066932 n/a Location (UCSC) Chr X: 12.98 – 12.98 Mb n/a PubMed search n/a Wikidata View/Edit Human Thymosin beta-4 is a protein that in humans is encoded by the TMSB4X gene. Recommended INN (International Nonproprietary Name) for thymosin beta-4 is 'timbetasin', as published by the World ...
Fluorescence polarization immunoassay (FPIA) is a class of in vitro biochemical test used for rapid detection of antibody or antigen in sample. FPIA is a competitive homogenous assay, that consists of a simple prepare and read method, without the requirement of separation or washing steps.