Ads
related to: gene knockout mice cd11c for sale texas classifieds craigslist
Search results
Results from the WOW.Com Content Network
There are several thousand different strains of knockout mice. [3] Many mouse models are named after the gene that has been inactivated. For example, the p53 knockout mouse is named after the p53 gene which codes for a protein that normally suppresses the growth of tumours by arresting cell division and/or inducing apoptosis.
3687 16411 Ensembl ENSG00000140678 ENSMUSG00000030789 UniProt P20702 Q9QXH4 RefSeq (mRNA) NM_000887 NM_001286375 NM_021334 NM_001363984 NM_001363985 RefSeq (protein) NP_000878 NP_001273304 NP_067309 NP_001350913 NP_001350914 Location (UCSC) Chr 16: 31.36 – 31.38 Mb Chr 7: 127.73 – 127.75 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CD11c, also known as Integrin, alpha X ...
A conditional gene knockout allows gene deletion in a tissue in a tissue specific manner. This is required in place of a gene knockout if the null mutation would lead to embryonic death, [13] or a specific tissue or cell type is of specific interest. This is done by introducing short sequences called loxP sites around the gene.
The consortium encompasses four major, high-throughput gene-targeted mutagenesis programs: the National Institutes of Health (NIH)-sponsored Knockout Mouse Program (KOMP) and state-funded Texas Institute for Genomic Medicine (TIGM) in the U.S., the North American Conditional Mouse Mutagenesis (NorCOMM) Program in Canada, and the European ...
Gene knock-in originated as a slight modification of the original knockout technique developed by Martin Evans, Oliver Smithies, and Mario Capecchi.Traditionally, knock-in techniques have relied on homologous recombination to drive targeted gene replacement, although other methods using a transposon-mediated system to insert the target gene have been developed. [3]
The International Mouse Phenotyping Consortium (IMPC) is an international scientific endeavour to create and characterize the phenotype of 20,000 knockout mouse strains. [1] [2] [3] Launched in September 2011, [1] the consortium consists of over 15 research institutes across four continents with funding provided by the NIH, European national governments and the partner institutions.
The gene can be later knocked out (inactivated) at a specific time-point or tissue-type in mutant mice derived from the mutant ES Cells, by appropriate breeding to other transgenic mice. This conditionality is a key property of the entire resource, and it allows a more nuanced study of the effects of the gene-knockout.
Genetic ablation occurs when a gene is deemed “null” through the homologous genetic recombination of a gene. It is utilized in the selective suppression of a specific cell line or cell type. This genetic engineering technique does not limit growth suppression to just the activity of an individual gene. [1]
Ads
related to: gene knockout mice cd11c for sale texas classifieds craigslist