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  2. Knockout mouse - Wikipedia

    en.wikipedia.org/wiki/Knockout_mouse

    There are several thousand different strains of knockout mice. [3] Many mouse models are named after the gene that has been inactivated. For example, the p53 knockout mouse is named after the p53 gene which codes for a protein that normally suppresses the growth of tumours by arresting cell division and/or inducing apoptosis.

  3. Integrin alpha X - Wikipedia

    en.wikipedia.org/wiki/Integrin_alpha_X

    3687 16411 Ensembl ENSG00000140678 ENSMUSG00000030789 UniProt P20702 Q9QXH4 RefSeq (mRNA) NM_000887 NM_001286375 NM_021334 NM_001363984 NM_001363985 RefSeq (protein) NP_000878 NP_001273304 NP_067309 NP_001350913 NP_001350914 Location (UCSC) Chr 16: 31.36 – 31.38 Mb Chr 7: 127.73 – 127.75 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CD11c, also known as Integrin, alpha X ...

  4. Gene knockout - Wikipedia

    en.wikipedia.org/wiki/Gene_knockout

    A conditional gene knockout allows gene deletion in a tissue in a tissue specific manner. This is required in place of a gene knockout if the null mutation would lead to embryonic death, [13] or a specific tissue or cell type is of specific interest. This is done by introducing short sequences called loxP sites around the gene.

  5. International Knockout Mouse Consortium - Wikipedia

    en.wikipedia.org/wiki/International_Knockout...

    The consortium encompasses four major, high-throughput gene-targeted mutagenesis programs: the National Institutes of Health (NIH)-sponsored Knockout Mouse Program (KOMP) and state-funded Texas Institute for Genomic Medicine (TIGM) in the U.S., the North American Conditional Mouse Mutagenesis (NorCOMM) Program in Canada, and the European ...

  6. Gene knock-in - Wikipedia

    en.wikipedia.org/wiki/Gene_Knock-in

    Gene knock-in originated as a slight modification of the original knockout technique developed by Martin Evans, Oliver Smithies, and Mario Capecchi.Traditionally, knock-in techniques have relied on homologous recombination to drive targeted gene replacement, although other methods using a transposon-mediated system to insert the target gene have been developed. [3]

  7. International Mouse Phenotyping Consortium - Wikipedia

    en.wikipedia.org/wiki/International_Mouse_Pheno...

    The International Mouse Phenotyping Consortium (IMPC) is an international scientific endeavour to create and characterize the phenotype of 20,000 knockout mouse strains. [1] [2] [3] Launched in September 2011, [1] the consortium consists of over 15 research institutes across four continents with funding provided by the NIH, European national governments and the partner institutions.

  8. EUCOMM - Wikipedia

    en.wikipedia.org/wiki/EUCOMM

    The gene can be later knocked out (inactivated) at a specific time-point or tissue-type in mutant mice derived from the mutant ES Cells, by appropriate breeding to other transgenic mice. This conditionality is a key property of the entire resource, and it allows a more nuanced study of the effects of the gene-knockout.

  9. Genetic ablation - Wikipedia

    en.wikipedia.org/wiki/Genetic_ablation

    Genetic ablation occurs when a gene is deemed “null” through the homologous genetic recombination of a gene. It is utilized in the selective suppression of a specific cell line or cell type. This genetic engineering technique does not limit growth suppression to just the activity of an individual gene. [1]

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