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2. Metformin - Wikipedia

   en.wikipedia.org/wiki/Metformin

   The US Food and Drug Administration (FDA) recommends avoiding the use of metformin in more severe chronic kidney disease, below the eGFR cutoff of 30 mL/minute/1.73 m 2. [94] Lactate uptake by the liver is diminished with metformin use because lactate is a substrate for hepatic gluconeogenesis, a process that metformin

3. History of diabetes - Wikipedia

   en.wikipedia.org/wiki/History_of_diabetes

   Identification of the first of the sulfonylureas in 1942; Reintroduction of the use of biguanides for type 2 diabetes in the late 1950s. The initial phenformin was withdrawn worldwide (in the U.S. in 1977) due to its potential for sometimes fatal lactic acidosis and metformin was first marketed in France in 1979, but not until 1994 in the US.

4. Diabetes medication - Wikipedia

   en.wikipedia.org/wiki/Diabetes_medication

   Metformin is a first-line medication used for treatment of type 2 diabetes. It is generally prescribed at initial diagnosis in conjunction with exercise and weight loss, as opposed to the past, where it was prescribed after diet and exercise had failed.

5. 6 Benefits of Taking Metformin (Besides Weight Loss) - AOL

   www.aol.com/6-benefits-taking-metformin-besides...

   One study among 96 patients diagnosed with gestational diabetes in the last three years found that, compared to insulin therapy, metformin had superior effects on blood sugar levels, inflammation ...

6. Weight Loss Injections: What You Need to Know, From ... - AOL

   www.aol.com/weight-loss-injections-know-costs...

   First, weight loss ... Metformin. Metformin is used for treating diabetes 2, ... An FDA-approved weight loss medication, naltrexone-bupropion is generally considered effective and safe to use. You ...

7. Diabetes management - Wikipedia

   en.wikipedia.org/wiki/Diabetes_management

   One of the most common drugs used in T2D, metformin is the drug of choice to help patients lower their blood sugar levels. Metformin is an example of a class of medicine called biguanides. [34] The medication works by reducing the new creation of glucose from the liver and by reducing absorption of sugar from food. [34]

8. Are Diabetes Drugs Really Safe (& Reliable) for Weight Loss?

   www.aol.com/diabetes-drugs-really-safe-reliable...

   Generally speaking, GLP-1s, GIP/GLP-1s, and metformin are considered safe and effective when used as prescribed. That said, no medication is without side effects.

9. Biguanide - Wikipedia

   en.wikipedia.org/wiki/Biguanide

   Therefore, they are effective in Type 2 diabetics; and in Type 1 diabetes when used in conjunction with insulin therapy. [citation needed] Mainly used in Type II diabetes, metformin is considered to increase insulin sensitivity in vivo, resulting in reduced plasma glucose concentrations, increased glucose uptake, and decreased gluconeogenesis.