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Metformin inhibits cyclic AMP production, blocking the action of glucagon, and thereby reducing fasting glucose levels. [117] Metformin also induces a profound shift in the faecal microbial community profile in diabetic mice, and this may contribute to its mode of action possibly through an effect on glucagon-like peptide-1 secretion. [108]
Marksans Pharma Limited has recalled metformin hydrochloride extended-release tablets due to their excessive levels of NDMA, a “probable human carcinogen,” noted the Food and Drug ...
Rank Brand Name(s) Generic Name Sales Q1 2014 Sales ($000) Change from Q4 2013 Company(ies) Disease/Medical Use First Approval Date Patent Expiration Date [6] [7]; 1: Abilify
Komen works on patient navigation and advocacy, providing resources for breast-cancer patients to understand the American medical system. [5] They have funded research into the causes and treatment of breast cancer. [6] However, the organization has been mired by controversy over pinkwashing, allocation of research funding, and CEO pay. The ...
A new cell study has shown the common type 2 diabetes medication metformin alters levels of microRNAs that target genes to slow down the growth and multiplication of colorectal cancer cells.
Apotex Inc. is a Canadian pharmaceutical corporation. [4] Founded in 1974 by Barry Sherman, the company is the largest producer of generic drugs in Canada, with annual sales exceeding CA$2.5 billion. [5]
Another meta-analysis of 33 studies involving 61,704 patients found that compared with non-metformin control groups, metformin usage among people with pre-existing cardiovascular conditions is ...
Gardasil 9 in French packaging (showing the MSD branding) The company develops medicines, vaccines, biologic therapies and animal health products. In 2020, the company had 6 blockbuster drugs or products, each with over $1 billion in revenue: Keytruda (pembrolizumab), a humanized antibody used in cancer immunotherapy that had $14.3 billion in 2020 revenue; Januvia (sitagliptin), an anti ...