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Pages in category "Aldosterone synthase inhibitors" The following 7 pages are in this category, out of 7 total. This list may not reflect recent changes. A.
It selectively stimulates secretion of aldosterone. The secretion of aldosterone has a diurnal rhythm. Control of aldosterone release from the adrenal cortex: [citation needed] The role of the renin–angiotensin system: Angiotensin is involved in regulating aldosterone and is the core regulator. Angiotensin II acts synergistically with potassium.
Drugs that interfere with the secretion or action of aldosterone are in use as antihypertensives, like lisinopril, which lowers blood pressure by blocking the angiotensin-converting enzyme (ACE), leading to lower aldosterone secretion. The net effect of these drugs is to reduce sodium and water retention but increase the retention of potassium.
Most esters of these corticosteroids are not included in this list; for esters, see here instead. The most common structural modifications in synthetic corticosteroids include 1(2)- dehydrogenation , 6α-, 9α-, 16α-, and 16β- substitution (with a halogen or methyl group ), 16α,17α- acetonidation , and 17α- and 21- esterification .
List of – steroidal antiandrogens; List of estrogens – estrogens; List of progestogens – progestogens; List of corticosteroids – corticosteroids, including both glucocorticoids and mineralocorticoids; List of neurosteroids – excitatory, inhibitory, mixed, neurotrophic, antineurotrophic, and other neurosteroids, as well as pheromones ...
Any chemical substance with biological activity may be considered a drug. This list categorises drugs alphabetically and also by other categorisations. This multi-page article lists pharmaceutical drugs alphabetically by name. Many drugs have more than one name and, therefore, the same drug may be listed more than once.
A mineralocorticoid receptor antagonist (MRA or MCRA) [1] or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors. This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure .
The name mineralocorticoid derives from early observations that these hormones were involved in the retention of sodium, a mineral. The primary endogenous mineralocorticoid is aldosterone , although a number of other endogenous hormones (including progesterone [ 1 ] and deoxycorticosterone ) have mineralocorticoid function.