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Linear least squares (LLS) is the least squares approximation of linear functions to data. It is a set of formulations for solving statistical problems involved in linear regression, including variants for ordinary (unweighted), weighted, and generalized (correlated) residuals.
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UniFrac, a shortened version of unique fraction metric, is a distance metric used for comparing biological communities.It differs from dissimilarity measures such as Bray-Curtis dissimilarity in that it incorporates information on the relative relatedness of community members by incorporating phylogenetic distances between observed organisms in the computation.
Weighted least squares (WLS), also known as weighted linear regression, [1] [2] is a generalization of ordinary least squares and linear regression in which knowledge of the unequal variance of observations (heteroscedasticity) is incorporated into the regression.
As regards weighting, one can either weight all of the measured ages equally, or weight them by the proportion of the sample that they represent. For example, if two thirds of the sample was used for the first measurement and one third for the second and final measurement, then one might weight the first measurement twice that of the second.
When treating the weights as constants, and having a sample of n observations from uncorrelated random variables, all with the same variance and expectation (as is the case for i.i.d random variables), then the variance of the weighted mean can be estimated as the multiplication of the unweighted variance by Kish's design effect (see proof):
Weighted means are commonly used in statistics to compensate for the presence of bias.For a quantity measured multiple independent times with variance, the best estimate of the signal is obtained by averaging all the measurements with weight = /, and the resulting variance is smaller than each of the independent measurements = /.
Unit-weighted regression is a method of robust regression that proceeds in three steps. First, predictors for the outcome of interest are selected; ideally, there should be good empirical or theoretical reasons for the selection.