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  2. BRAF (gene) - Wikipedia

    en.wikipedia.org/wiki/BRAF_(gene)

    BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known as serine/threonine-protein kinase B-Raf.

  3. Canine degenerative myelopathy - Wikipedia

    en.wikipedia.org/wiki/Canine_degenerative_myelopathy

    A dog with degenerative myelopathy often stands with its legs close together and may not correct an unusual foot position due to a lack of conscious proprioception. Canine degenerative myelopathy, also known as chronic degenerative radiculomyelopathy, is an incurable, progressive disease of the canine spinal cord that is similar in many ways to amyotrophic lateral sclerosis (ALS).

  4. V600E - Wikipedia

    en.wikipedia.org/wiki/V600E

    V600E is a mutation of the BRAF gene in which valine (V) is substituted by glutamic acid (E) at amino acid 600. [1] [2] It is a driver mutation in a proportion of certain diagnoses, including melanoma, [3] [4] hairy cell leukemia, [5] [6] papillary thyroid carcinoma, [7] [8] colorectal cancer, [9] non-small-cell lung cancer, [10] [11] Langerhans cell histiocytosis, [12] Erdheim–Chester ...

  5. Bladder cancer - Wikipedia

    en.wikipedia.org/wiki/Bladder_cancer

    Urine tests can aid in diagnosis; they test for the protein bladder tumor antigen (high in bladder tumors) or mutations in the BRAF gene (present in around 80% of dogs with bladder or prostate cancer). [73] Dogs with confirmed cancer are treated with COX-2 inhibitor drugs, such as piroxicam, deracoxib, and meloxicam.

  6. MEK inhibitor - Wikipedia

    en.wikipedia.org/wiki/MEK_inhibitor

    Cobimetinib or XL518, approved by US FDA in Nov 2015 for use in combination with vemurafenib (Zelboraf(R)), for treatment of advanced melanoma with a BRAF V600E or V600K mutation. Selumetinib , had a phase 2 clinical trial for non-small cell lung cancer (NSCLC) which demonstrated an improvement in PFS, [ 5 ] and is now in phase III development ...

  7. Veterinarian Explains Negative Vaccine Reactions in Dogs ...

    www.aol.com/veterinarian-explains-negative...

    The vet gave the same treatment. However, each time I tried to give her the regular commercial dog food diet, the diarrhea with blood returned. At one point, she developed the 'squirts,' similar ...

  8. Dabrafenib - Wikipedia

    en.wikipedia.org/wiki/Dabrafenib

    Dabrafenib is indicated as a single agent for the treatment of people with unresectable or metastatic melanoma with BRAF V600E mutation. [2] Dabrafenib is indicated, in combination with trametinib, for BRAF V600E-positive unresectable or metastatic melanoma, metastatic non-small cell lung cancer, metastatic anaplastic thyroid cancer, and unresectable or metastatic solid tumors.

  9. Bedinvetmab - Wikipedia

    en.wikipedia.org/wiki/Bedinvetmab

    Half the dogs received bedinvetmab and half the dogs received a sterile saline injection every 28 days for a total of three doses. [5] Before treatment and on various days throughout the study, owners used the Canine Brief Pain Inventory (CBPI) assessment tool to measure the severity of the dog's pain and the degree to which the pain interfered ...