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  2. Adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_receptor

    The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta blockers, beta-2 (β 2) antagonists and alpha-2 (α 2) agonists, which are used to treat high ...

  3. Beta-1 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Beta-1_adrenergic_receptor

    The beta-1 adrenergic receptor (β 1 adrenoceptor), also known as ADRB1, can refer to either the protein-encoding gene (gene ADRB1) or one of the four adrenergic receptors. [5] It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein that is expressed predominantly in cardiac tissue. In addition to cardiac tissue, beta ...

  4. Beta-2 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Beta-2_adrenergic_receptor

    The beta-2 adrenergic receptor (β 2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline), a hormone and neurotransmitter whose signaling, via adenylate cyclase stimulation through trimeric G s proteins, increases cAMP, and, via downstream L-type calcium channel interaction, mediates physiologic responses such as smooth ...

  5. Beta-3 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Beta-3_adrenergic_receptor

    155 11556 Ensembl ENSG00000188778 ENSMUSG00000031489 UniProt P13945 P25962 RefSeq (mRNA) NM_000025 NM_013462 RefSeq (protein) NP_000016 NP_038490 Location (UCSC) Chr 8: 37.96 – 37.97 Mb Chr 8: 27.23 – 27.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The beta-3 adrenergic receptor (β 3 -adrenoceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the ...

  6. G protein-coupled receptor - Wikipedia

    en.wikipedia.org/wiki/G_protein-coupled_receptor

    Crystal structure of activated beta-2 adrenergic receptor in complex with G s (PDB entry 3SN6). The receptor is colored red, Gα green, Gβ cyan, and Gγ yellow. The C-terminus of Gα is located in a cavity created by an outward movement of the cytoplasmic parts of TM5 and 6.

  7. Adrenergic receptor autoantibodies - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_receptor_auto...

    The binding to these receptors by catecholamines will generally stimulate the sympathetic nervous system, the arm of the autonomic nervous system responsible for the fight-or-flight response. Adrenergic receptor autoantibodies are autoantibodies (antibodies directed against a person's own protein) targeting adrenergic receptors.

  8. Beta-adrenergic agonist - Wikipedia

    en.wikipedia.org/wiki/Beta-adrenergic_agonist

    Activation of β 2 receptors induces smooth muscle relaxation in the lungs, gastrointestinal tract, uterus, and various blood vessels. Increased heart rate and heart muscle contraction are associated with the β1 receptors; however, β 2 cause vasodilation in the myocardium. [citation needed] β3 receptors are mainly located in adipose tissue. [5]

  9. G protein-coupled receptor kinase 2 - Wikipedia

    en.wikipedia.org/wiki/G_protein-coupled_receptor...

    G-protein-coupled receptor kinase 2 (GRK2) is an enzyme that in humans is encoded by the ADRBK1 gene. [5] GRK2 was initially called Beta-adrenergic receptor kinase (βARK or βARK1), and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar to GRK3(βARK2).