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Estrone sulfate, also known as E1S, E1SO4 and estrone 3-sulfate, is a natural, endogenous steroid and an estrogen ester and conjugate. [1] [2] [3]In addition to its role as a natural hormone, estrone sulfate is used as a medication, for instance in menopausal hormone therapy; for information on estrone sulfate as a medication, see the estrone sulfate (medication) article.
Estrone sulfate, the 3-sulfate conjugate of estrone. Estriol glucuronide, the 16α-glucuronide conjugate of estriol. An estrogen conjugate is a conjugate of an endogenous estrogen. They occur naturally in the body as metabolites of estrogens and can be reconverted back into estrogens.
E1S, also known as estrone 3-sulfate or as estra-1,3,5(10)-trien-17-one 3-sulfate, is a naturally occurring estrane steroid and a derivative of estrone. [15] It is an estrogen conjugate or ester, and is specifically the C3 sulfate ester of estrone. [15] Salts of E1S include sodium estrone sulfate and estropipate (piperazine estrone sulfate ...
[1] [12] [11] Sodium estrone sulfate is a prodrug of estrone, which in turn is a prodrug of estradiol, while sodium equilin sulfate is a prodrug of equilin and then of 17β-dihydroequilin. [1] As such, the major active estrogens with CEEs are estradiol and 17β-dihydroequilin, which have potent estrogenic activity and account for most of the ...
[5] [65] [66] The metabolic clearance rate of estrone is 1,050 L/day/m 2 and of estradiol is 580 L/day/m 2, while that of estrone sulfate is 80 L/day/m 2. [5] For comparison, the metabolic clearance rate of estriol is 1,110 L/day/m 2. [5] A single 1 to 2 mg dose of estrone in oil solution by intramuscular injection has a duration of about 2 or ...
Steroid sulfation is one of the most common of all forms of steroid conjugation. Except for cholesterol, dehydroepiandrosterone sulfate is the most abundant of all plasma steroids. Estrone sulfate is the most abundant of all the estrogens in the human body. [3] Estrone sulfate is synthesized by the enzyme estrone sulfotransferase.
About 15% of orally administered estradiol is transformed into estrone and 65% into estrone sulfate. [12] About 5% of estrone and 1.4% of estrone sulfate is converted back into estradiol. [12] An additional 21% of estrone sulfate is converted into estrone, whereas transformation of estrone into estrone sulfate is approximately 54%. [12]
Conjugated estrogens (brand name Premarin), an estrogen product manufactured from the urine of pregnant mares and commonly used in menopausal hormone therapy, is a mixture of natural estrogens including estrone sulfate and equine estrogens such as equilin sulfate and 17β-dihydroequilin sulfate. [1]