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Postherpetic neuralgia (PHN) is neuropathic pain that occurs due to damage to a peripheral nerve caused by the reactivation of the varicella zoster virus (herpes zoster, also known as shingles). PHN is defined as pain in a dermatomal distribution that lasts for at least 90 days after an outbreak of herpes zoster. [ 1 ]
This particular nerve is best described by Dr. Huelke in 1958. Dr. Huelke took the original modern cadaveric studies (from the turn of the 20th century) and wrote a treatise titled "The origin of the peroneal communicating nerve" that describes the origins and pathways of the peroneal communicating nerve. He did this research in such a way that ...
Thus, the prefrontal input to the ANS modulate the inflammatory response to psychological stress in part via the cholinergic anti-inflammatory pathway. [14] In recent years, this PFC-Vagus Nerve-Spleen axis has been linked to cellular senescence [15] [16] and various pathologies such as neurodegenerative diseases and cancer. [17] [18]
Shingles, also known as herpes zoster or zona, [6] is a viral disease characterized by a painful skin rash with blisters in a localized area. [2] [7] Typically the rash occurs in a single, wide mark either on the left or right side of the body or face. [1]
Inflammatory demyelinating diseases (IDDs), sometimes called Idiopathic (IIDDs) due to the unknown etiology of some of them, are a heterogenous group of demyelinating diseases - conditions that cause damage to myelin, the protective sheath of nerve fibers - that occur against the background of an acute or chronic inflammatory process.
Preherpetic neuralgia is a form of nerve pain specifically associated with a Shingles (herpes zoster) viral infection. This nerve pain often precedes visible indications of a Shingles infection and consequently can be a key early indicator of a need to begin preventative anti-viral drug therapy.
A skin biopsy for the measurement of epidermal nerve fiber density is an increasingly common technique for the diagnosis of small fiber peripheral neuropathy. [13] Physicians can biopsy the skin with a 3-mm circular punch tool and immediately fix the specimen in 2% paraformaldehyde lysine-periodate or Zamboni's fixative. [ 20 ]
In a nerve decompression, a surgeon explores the entrapment site and removes tissue around the nerve to relieve pressure. [57] In many cases the potential for nerve recovery (full or partial) after decompression is excellent, as chronic nerve compression is associated with low-grade nerve injury ( Sunderland classification I-III) rather than ...